1. http://mri.med.cornell.edu Magnetic Resonance Imaging Yi Wang, PhD Imaging Physics Hardware/Software Clinical/Biological Application Nguyen, Spincemaille, de Rochefort, Brown, Kressler, Codella, Singh, Lee, Wang, Zabih Prince, Kent, Weinsaft, Cheng, Morrisett, Cham….

2. Imaging Physics Study Spin Dynamics –interaction of body tissue (p) with magnetic field (B) –B pulses for probing tissue kzkz kyky kxkx Image Formation –spatial encoding (Fourier k) in signal detection –k-space sampling –pulse sequences for tissue morphology & function

3. Technology Development - hardware RF coils: cardiac coil, bilateral peripheral coil High performance computing: 34 node cluster

4. Technology Development - software Fast imaging sequences: time resolved 4D spiral, fgre, ssfp, fse Navigator motion suppression: diaphragm navigator, cardiac fat navigator

5. Carotid MRA

6. Navigator Cardiac MRI 4D Cardiac MRI

7. Peripheral MRA 4D MRA

8. Functional peripheral MRI - perfusion 1 st pass perfusion quantifies ischemia Delayed enhancement predicts ulcer Perfusion/DE characterizes wound healing?

9. Functional peripheral MRI – vessel wall TOF T1 T2 PD Rich tissue contrast to characterize plaque and monitor statin therapy.

10. Magnetization/susceptibility MRI Cunningham et al MR-SQUID: Magnetic resonance susceptibility quantification using inversion of dipole fields. In vivo imaging of biochemical reaction? Quantification of magnetically labeled cellular MRI?

11. Thank You!