1. Local Area Network (LAN) Database Asset Manager Application Server

2. HDI Differentiation Score Monthly Cost. SOC $100$87.5 $75 1 Cost HDI Differentiation Score Table % of Scale better than nearest competitor HDI Differentiation Score <0%1 0% - 15%3 16% - 30%5 31%-45%7 46% - 100%9 Monthly Cost. SOC $100$87.5 $75 5 Cost Example 1 – Negative Differentiation. When the highest range of performance of the Target Performance (A) is less that any of the Competitors, then the subject Asset has “negative” differentiation for this Parameter. In this case the Stakeholders (Patients, Payers, etc.) will likely chose one of the competitors for this Parameter. Example 2 – Positive Differentiation. When the highest range of performance of the Target Performance (A) is to greater than (to the right of) that any of the Competitors, then the subject Asset has “positive” differentiation for this Parameter. In this case the Stakeholders (Patients, Payers, etc.) will likely chose the subject Asset over any of the competitors for this Parameter. (A) (B) (A) Calculating the HDI Differentiation Score. 1.Calculate the difference between the Target Performance and the best performing Competitor (A) – (B) Looking at Example 2: ABS(77-83) =6 2.Divide that amount by the range of data for this Parameter (the left most value for the Target Performance of any of the Competitors verses the rightmost value) Looking at Example 2: 100-77=23 6/23=26% 3.Look up that % in the HDI Differentiation Score Table to determine the Differentiation Score for this Parameter. Looking at Example 2: 26% falls in the range on the 3rd Row in the table (16%-30%) which relates to a Differentiation Score of 5.

3. HDI Differentiation Score Table % of Scale better than nearest competitor HDI Differentiation Score <0%1 0% - 15%3 16% - 30%5 31%-45%7 46% - 100%9 HDI Differentiation Score (1 – Negative Differentiation) Competitors perform better than Target Performance for this Parameter. HDI Score: Stakeholders will favor at least one of the Competitive products over the subject Asset, and therefore the subject Asset does not have an advantage over the Competitive products for this Parameter. The HDI Differentiation Score is a 1. Monthly Cost. SOC $100$87.5 $75 1 Cost

4. HDI Differentiation Score Table % of Scale better than nearest competitor HDI Differentiation Score <0%1 0% - 15%3 16% - 30%5 31%-45%7 46% - 100%9 HDI Differentiation Score (3 – Low Differentiation) Monthly Cost SOC $100$95$90$75 3 $85$80 Cost Target Performance for this Parameter ($75) is better than closest competitor ($77), but not by much. In fact, only 8% of scale (77-75) / 25 = 8%. HDI Score: For this particular Parameter, stakeholders will slightly favor the subject Asset, and therefore the HDI Differentiation Score is a 3. <8% of Data Range

5. HDI Differentiation Score Table % of Scale better than nearest competitor HDI Differentiation Score <0%1 0% - 15%3 16% - 30%5 31%-45%7 46% - 100%9 # of patients with adverse events. SOC 10 50 7 Safety HDI Differentiation Score (7 – Significant Differentiation ) Target Performance (1) is better than the nearest competitor (5.5) by 45% of data range for this Parameter (5.5 – 1 ) / 10 = 45%. HDI Score: For this particular Parameter, stakeholders will significantly favor the subject Asset because it will out perform all of the competitors by more than 40%, and therefore the HDI Differentiation Score is a 7. 45% of Chart Range

6. HDI Differentiation Score Table % of Scale better than nearest competitor HDI Differentiation Score <0%1 0% - 15%3 16% - 30%5 31%-45%7 46% - 100%9 % of patients with decreased energy levels. SOC 100%75% 50%0% 9 25% Tolerability HDI Differentiation Score (9 – Significant Differentiation) Range between highest level of Competitor performance (65%) and Target Performance for subject Asset (10%) is 50% of data range for this Parameter. HDI Score: For this particular Parameter, stakeholders will strongly favor the subject Asset because it will out perform all of the competitors by more than 50% of the data range for this Parameter, and therefore the HDI Differentiation Score is a 9. 55% of Chart Range

7. MEDiff Decision Support Asset ManagerBusiness Leaders (Governance Body) Improve Information Rigor/Reliability Continue to research competitor information, Unmet Needs, and trial/study results to improve the quality and depth of information supporting this asset. Add support to Asset development Clear differentiation on key Unmet Needs warrants additional investment to accelerate development Compared to Portfolio, this Asset projects top quartile ROI, add support to accelerate Asset presents compelling opportunity but requires additional support to develop further Manage Asset Development Ensure dates/commitments are met by monitoring progress, adjusting resources as needed Facilitate process to identify Unmet Needs (CVS), identify and maintain appropriate Parameters (HDI), Indentify and capture Competitor information, update RWW analysis Realign Efforts: Differentiation is unclear, not compelling or not addressing key Unmet Needs, focus shifted to address Unmet Needs Refocus Efforts: Achieve greater differentiation in key areas Stop Development of this Asset: Potential not panning out in key Unmet Needs categories, Asset is underperforming compared to Portfolio. Additional investment is unwarranted. Information about disease area – competition, parameters, competition raking by parameter, typical CVSs for Disease Area – also helps design & speed up protocol Provides standard process to accelerate workload Way to facilitate various functions coming together – e.g,.HDI require safety, mfg, commericial, access community

8. System Screens AO (Asset Overview) Competitors CVS (Customer Value Statements) HDI (Healthcare Differentiation Instrument) LDS (Label Differentiation Strategy) MA (Market Access) RWW (Real, Win Worth) Scale (HDI Parameter Scale)