1. Endocrine Slide Show

2. Question 1 1.Name two clinical signs in the photo 2.Likely diagnosis 3.Name another sign of this condition

3. Question 1 1.Exopthalmos & Goitre 2.Grave’s Disease 3.Pretibial myxoedema (see photo) Lid lag

4. Question 2 Diagnosis? What would the blood abnormalities be if this person wasn’t dead? What other investigations might you do?

5. Question 2 Paget’s High Alk Phos Normal Calcium (may be slightly raised if ++ patient immobility) Urinary hydroxyproline (raised in Paget’s) X-rays (localised bone elargement, sclerotic bones) DEXA scan (high bone turnover in spine, skull & long bones)

6. Question 3 Diagnosis? Name 4 features visible in this image

7. Question 3 BACKGROUND diabetic retinopathy See diagram

8. Question 4 Diagnosis? Expected blood results? Management?

9. Question 4 Hypothyroidism/a bit fat TSH >5mu/L & T4 < 70mmol/L (1°) or normal TSH (2°) Levothyroxine

10. Question 5 Diagnosis? Expected test results? Management?

11. Question 5 Cushing’s Syndrome (or too many pies) Remove tumour (if Cushing’s disease) Stop steroids (if iatrogenic)

12. Question 6 What’s the diagnosis? –JFK had fatigue, wt loss, weakness, depression, N&V, diarrhoea and fainting How would you confirm your diagnosis?

13. Question 6 Addison’s Low Na, High K, Low Glucose, Low Cortisol, High Ca, eosinophilia, anaemia

14. Question 7 Spot diagnosis? Causes?

15. Question 7 Hirsutism Familial Idiopathic PCOS Ovarian Ca CAH Cushing’s Drugs (steroids)

16. Question 8 Calcium – high Alk Phos – high Phosphate – high 25 OH vitamin D – low Diagnosis?

17. Question 8 Osteomalacia

18. Question 9 K+ - high Na+ - slightly high Metabolic alkalosis Low renin High aldosterone Diagnosis?

19. Question 9 K+ - high Na+ - slightly high Metabolic alkalosis Low renin High aldosterone Conn’s syndrome

20. Question 10 Diagnosis? Management?

21. Question 10 Paget’s Simple analgesia & bisphosphonates