1. Margarita Valero Juan Physical Chemistry Department Pharmacy Faculty Salamanca University Micelles as Drug Carriers for Controlled Release ATHENS 2014

2. SALAMANCA, SPAIN Margarita Valero

3. SALAMANCA MAIN SQUARE

4. SALAMANCA CATHEDRAL

6. PHARMACY FACULTY

7. Physical Chemistry Department

8. 1.- Colloidal Systems Dispersed particles (10 -6 m to 10 -9 m) (  -nm) SolutionsMacrodispersions Dispersed particles: A: liophilic: are soluble in the dispersant medium: aggregation colloids or polymers B: liophobic: are not soluble in the dispersant medium: -emulsions (liquid/liquid) -suspensions (solid/liquid)

9. 2.- Micelles Formation APOLARPOLAR INNER SOLUTION (DISSOLVED) INTERFACE (ADSORBED) HYDROPHOBIC SURFACE HYDROPHYLIC SURFACE

10. NON IONICS IONICS H2OH2O H2OH2O H2OH2O H2OH2O H2OH2O H2OH2O H2OH2O H2OH2O H2OH2O H2OH2O H2OH2O H2OH2O H2OH2O H2OH2O H2OH2O H2OH2O “PALISADE LAYER” x+x+ x+x+ x+x+ x+x+ x+x+ x+x+ x+x+ x+x+ - x+x+ - - - - - - - - - - - - - - - x+x+ x+x+ x+x+ x+x+ FIX LAYER:”STERN ” DIFUSSE LAYER:”GOUY ” DOBLE ELECTRIC LAYER : “GOUY CHAPMAN” Electrical Potential Potential Value:Zeta potenlial (ξ) 3.- Stucture of Micelles

11. LOADDING + molecules polarity KPKP K P : Partition KP=KP= [molecule] micelle [molecule] H 2 O 4.- Properties of Micelles

12. MICROEMULSIÓN 5.- Solubilization and Microemulsions

13. 6.- Other Types of Micelles and Aggregates

14. PHOTOPHYSICS PROCESSES  = --------------------------------------- PHOTONS DEACTIVATED ABSORBED PHOTONS  : lifetime max F em  abs = Stokes Shift * QUENCHIG 6.- Fluorescence Spectroscopy

15. BIOLUMINISCENCE

16. BIOLUMINISCENCE

17. BIOLUMINISCENCE

18. Borealis Aurorae