1. Boston College Carroll School of Management Genzyme Corporation: Corporate Culture Frank Ollington, Ph.D. September 15, 2008

2. 2 Outline Personal Introduction Genzyme Introduction Genzyme description of culture What we say it is…how we (try to) describe it… Discussion... Wrap up

3. 3 Brief biography …at Genzyme… Science Diagnostics Operations Therapeutics Operations BU President - Pharmaceuticals Corporate-wide Operations Program Management August 29, 1988 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - > ? Frank Ollington

4. 4 Genzyme - Our Global Corporation Founded 1981 >10,000 employees worldwide Helping patients in nearly 90 countries 17 manufacturing sites 9 genetic testing lab sites 16 major marketed products 2007 revenue of $3.8 billion 80 locations in >40 countries

5. 5 Our Focus We develop breakthrough therapies to meet unmet medical needs We are committed to make a significant improvement in patients lives We are patient focused

6. 6 Our Revenue Growth $ $ In Millions

7. 7 Our Major Commercial Units & Products Thymoglobulin ® Renvela ® Renal Renagel ® Fabrazyme ® Genetic Diseases Aldurazyme ® Cerezyme ® Oncology/ Endocrinology Synvisc ® Sepra TM Products Orthopaedics/ Biosurgery Carticel ® MACI ® Thyrogen ® Campath ® Clolar ® Transplant/ Immune Disease Myozyme ® Genetics/ Diagnostics Reproductive Oncology Infectious Disease Cardiovascular Hectorol ® Synvisc-One TM 12 Products are no. 1 in their markets

8. 8 Awards and Recognition Consistently named a top employer by Science magazine Rated one of the most generous in-kind givers in BusinessWeek surveys Named to the Dow Jones Sustainability World Index for the past four years. Genzyme Center recognized as one of the most environmentally responsible U.S. buildings Genzyme was named one of 2007’s most ethical companies by Ethisphere magazine. Awarded the National Medal of Technology

9. 9 A Proven Business Model Market leadership: high value clinical products Global infrastructure: vertical integration creates leverage Experienced organization: across all businesses/functions Diversified base: enables opportunities / reduces risks Strong pipeline: expanded indications, larger markets

10. 10 Drive Innovation Our Core Values Entrepreneurialism Integrity Compassion Collaboration

11. 11 Drive Innovation Some of Our Core Values Entrepreneurialism Integrity Compassion Collaboration

12. 12 A Defining Corporate Mission Taking Care of Patients Globally

13. 13

14. 14 Our Cultural Foundation Do the right thing for patients Never “give up” Exhibit courage Think honestly, flexibly and outside the box Stay grounded, stay real Ricky and Fernando Fabry patients

15. 15 Our Cultural Foundation Hire great people Give them the room to “be great” Utilize the strength of the team Family feeling built on respect, caring and success Build a sustainable company that we will still want to work in Aline Moreno, Regulatory Affairs Genzyme do Brazil

16. 16 So why talk about Culture? We, Genzyme, define ourselves and our way of doing things through our Culture, not through rigid rules

17. 17 Our Culture Our Culture reflects our values and binds us closely together as one family with a clear focus, a common mission and a shared style.

18. 18 Our Culture Our Culture creates a multi-dimensional space in which each of our great people (each of you) has the freedom and the opportunity to think, act, lead, innovate, team, achieve, and excel-- that is, to be great! But it isn’t really just an opportunity– it is a commitment we make to each other – it is an obligation to the group.

19. 19 Genzymeness:Innovation Success results from Innovation Innovation is the result of Taking Chances Taking Chances requires: A Positive Nurturing Environment (CULTURE) GREAT PEOPLE determined to think and act

20. 20 Henri Termeer - CEO Genzyme “Everything we do is all about innovation, taking risks, being first. Innovation is absolutely an attitude.” Boston Globe 100: Executive Roundtable; May 2008 “When we decide to do less risky things, when we decide to take on small problems so that we can be sure they’ll work, that’s the signal that we’re losing our edge. We may still be a good economic enterprise, but I think we lose our right to exist.” Boston Magazine; June, 2008

21. 21 Genzymeness:Personal Commitment Success results from a personal Commitment to achieve Results It’s not the process, it’s the result Find a way Think outside the box Demonstrate courage Never give up Etc, etc

22. 22 We Succeed By Strong Individuals Working As A Strong Team Someone (why not YOU?) must be a catalyst for action, must start a team Aggressively Collaborate Never Give Up Using All Our Strengths

23. 23 Genzymeness:The Matrix Embrace and Harness the Matrix

24. 24 Organizational Matrix

25. 25 Genzymeness:The Matrix Embrace and Harness the Matrix Network like crazy Build and nurture relationships Don’t be shy Don’t be too proud Use it, don’t fight it Etc, etc

26. 26 Genzymeness: Personal Leadership Personal Pride is fundamental Personal Responsibility Personal Discipline Personal Initiative are critical components Personal Freedom increases as a result

27. 27 EXPAND YOUR PERSONAL LEADERSHIP STYLE AND SKILLS Nurture “Genzymeness” Understand the Culture Keep It Live, Help it Evolve Live the Culture Every Day Set an Example Apply It to All You Do Teach the Culture Don’t be Shy! Speak Up! Act!

28. 28 Achieve the “Impossible” The Genzyme Way -- By Keeping The Patient As Our Guiding Light!

29. 29 Right…

30. 30 Genzyme Culture What, if anything, does all that mean to you? What kind of people thrive at Genz? Benefits/upsides of working in such a culture – and the downsides…? How do you think the matrix organization affects Genz culture?

31. 31 End

32. 32 “Tip Book” … If I had one recommendation Show confidence and belief in yourself People do well at Genzyme when they can manage across the silos Build relationships with “go-to” people in each area or function…not just your direct contacts and the heads of the units…to get things done Show your passion; we like inspirational leadership Always take the high road and make the time for relationships; you will be here a long time Walk a mile in the other person’s shoes Are you able to shepherd a project to success? This is key at Genzyme What you do with and through others at Genzyme makes you successful here Values are your compass when a decision is difficult Always ask when given an assignment-- who are the three-five key people I should reach out to. When you are asked to become involved, ask who else the person has spoken with…when you hear the names, you will be able to gauge the chances of success.