1. 10.2 CellDivision Prokaryotes: just separate into two Eukaryotes: Two stages mitosis division of nucleus cytokinesis dividing cytoplasm in two Chromosomes: Only visible during cell division At other times chromatin At cell division, chromosomes have been duplicated, and so are seen as two sister chromatids

2. Chromosomes Only visible during cell division At cell division, chromosomes have been duplicated and are seen as two sister chromatids joined at centromere

3. Chromosomes: DNA twisted together with proteins histones Then twisted again and again into chromatids

4. Cell Cycle Interphase: time between divisions cell growth duplication of genetic material Mitosis: nucleus and chromosomes divide Cytokinesis: cytoplasm divides

5. Cell Cycle

6. Interphase: time between divisions

7. Cell Cycle Prophase: Chromatin organizes into chromosomes. Nuclear membrane breaks up

8. Cell Cycle Metaphase: Chromosomes line up along cell equator

9. Cell Cycle Anaphase: Chromosomes separate toward opposite poles

10. Cell Cycle Telophase: Nuclear membrane reformes. Cytokinesis begins.

11. Cell Division: Mitosis

13. 10.3 Regulating the Cell Cycle A. Controls on Cell Division Cells in a petri dish

14. 10.3 Regulating the Cell Cycle A. Controls on Cell Division Cells in a petri dish

15. 10.3 Regulating the Cell Cycle A. Controls on Cell Division Cells in a petri dish

16. 10.3 Regulating the Cell Cycle A. Controls on Cell Division Cells in a petri dish

17. 10.3 Regulating the Cell Cycle A. Controls on Cell Division Cells in a petri dish

18. 10.3 Regulating the Cell Cycle B. Cell Cycle Regulators Cyclins Regulate timing of cell cycle 1.Internal Regulators cell won’t enter mitosis until chromosomes are replicated cell won’t enter anaphase until chromosomes are attached to the spindle

19. 10.3 Regulating the Cell Cycle 2. External Regulators wound healing embryo development

20. 10.3 Regulating the Cell Cycle C. Uncontrolled Cell Growth Cancer cells to not respond to usual regulatory signals, resulting in tumors. Gene p53 “Cancer is a disease of the cell cycle”