1. Neurobiology of Schizophrenia, Mood Disorders, and Anxiety Disorders
Chapter 18

2. Schizophrenia
Schizophrenia is a term coined by Eugene Bleuler in 1911 to describe a collection of illnesses characterized by thought disorders
Psychotic episode
Genetic predisposition
Prenatal and perinatal
Neuroanatomic alterations
Neurotransmitter alterations

3. Schizophrenia

4. Schizophrenia

5. Schizophrenia Clinical manifestations Hallucinations Delusions
Disorganized behavior
Disorganized speech
Negative symptoms
Affective flattening
Anhedonia, alogia, and avolition

6. Mood Disorders Mood refers to a sustained emotional state
Affective states are brief emotional feelings
Euphoria, joy surprise, fear, sadness, etc.
Depression
States such as sadness become prominent

7. Mood Disorders Categories of mood disorder Genetic predisposition
Unipolar
Also known as major depression or clinical depression
Bipolar disorder
Genetic predisposition
Environmental influences

8. Mood Disorders Neurochemical dysregulation
Neuroendocrine dysregulation
Hypothalamic-pituitary-adrenal system dysregulation
Hypothalamic-pituitary-thyroid system dysregulation
Neuroanatomic and functional abnormalities

9. Mood Disorders Clinical manifestations Treatment Depression Mania
Antidepressants
Psychotherapy
Combination of both

10. Mood Disorders

11. Mood Disorders

12. Anxiety Disorders Panic disorder Generalized anxiety disorder
Posttraumatic stress disorder
Obsessive-compulsive disorder