1. Human Anatomy and Physiology: Unit 2 Part 2 Unit 2 Part 2: Tissues Chapter 4 © 2013 Pearson Education, Inc.

2. Chapter 4 Learning Targets 4-1 Identify the body's four basic types of tissues and describe their roles. 4-2 Describe the characteristics and functions of epithelial cells. 4-3 Describe the relationship between form and function for each type of epithelium. 4-4 Compare the structures and functions of the various types of connective tissues.

3. © 2013 Pearson Education, Inc. Chapter 4 Learning Targets 4-5 Explain how epithelial and connective tissues combine to form four types of tissue membranes, and specify the functions of each. 4-6 Describe the three types of muscle tissue and the special structural features of each. 4-7 Discuss the basic structure and role of neural tissue. 4-8 Explain how injuries affect the tissues of the body. 4-9 Describe how aging affects the tissues of the body.

4. © 2013 Pearson Education, Inc. Tissues (4-1) Collections of cells and cell products that perform specific, limited functions Histology The study of tissues Four types of tissues 1.Epithelial 2.Connective 3.Muscle 4.Neural

5. © 2013 Pearson Education, Inc. CELLS That secrete and regulate EXTRACELLULAR MATERIAL AND FLUIDS EPITHELIAL TISSUE Covers exposed surfaces Lines internal passageways and chambers Produces glandular secretions CONNECTIVE TISSUE Fills internal spaces Provides structural support Stores energy MUSCLE TISSUE Contracts to produce active movement NEURAL TISSUE Conducts electrical Impulses Carries information Combine to form TISSUES with special functions Combine to form ORGANS with multiple functions Interact in ORGAN SYSTEMS Chapters 5–20 Figure 4-1 An Orientation to the Tissues of the Body.

6. © 2013 Pearson Education, Inc. Checkpoint (4-1) 1.Define histology. 2.List the four basic types of tissues in the body.

7. © 2013 Pearson Education, Inc. Epithelial Tissue (4-2) Covers body surfaces Lines cavities Lines tubular structures Serves essential functions

8. © 2013 Pearson Education, Inc. Functions of Epithelia (4-2) Provide physical protection Control permeability Provide sensation Produce specialized secretions (glandular epithelium) Exocrine glands- secretions are discharged outside the epithelium (ex. Perspiration from skin glands) Endocrine glands- secretions are discharged within the tissue fluid and blood (ex. Hormones)

9. © 2013 Pearson Education, Inc. Figure 4-3 The Surfaces of Epithelial Cells. Cilia Microvilli Apical surface Golgi apparatus Nucleus Mitochondria Basement membrane

10. © 2013 Pearson Education, Inc. Epithelial Renewal and Repair (4-2) Epithelia are replaced by mitosis Cell division of stem cells (germinative cells) Occurs near basement membrane

11. © 2013 Pearson Education, Inc. Checkpoint (4-2) 3.List five important characteristics of epithelial tissue. 4.Identify four essential functions of epithelial tissue. 5.Identify the three main types of epithelial cell junctions. 6.What physiological functions are enhanced by the presence of microvilli or cilia on epithelial cells?

12. © 2013 Pearson Education, Inc. Classification of Epithelia (4-3) Combines a cell shape with the number of layers of cells Example: Simple (one layer) cuboidal (square shape)

13. © 2013 Pearson Education, Inc. Cell Layers and Cell Shapes (4-3) Classification is based on layers Simple epithelium: single layer of cells Stratified epithelium: several layers of cells Classification is based on shape Squamous epithelia: thin and flat Cuboidal epithelia: square shaped Columnar epithelia: tall, slender rectangles

14. © 2013 Pearson Education, Inc. Table 4-1 Classifying Epithelia

15. © 2013 Pearson Education, Inc. Cell Layers and Cell Shapes (4-3) Simple squamous epithelium: Location: kidneys, lungs, heart, lining of ventral body cavity Function: absorption, secretion, reduce friction Simple coboidal epithelium: Location: glands, ducts, kidneys, and thyroid gland Function: some protection, secretion, and absorption Simple columnar epithelium Location: stomach, intestines, gall bladder, uterus, and kidneys Function: some protection, secretion, absorption

16. © 2013 Pearson Education, Inc. Cell Layers and Cell Shapes (4-3) Stratified squamous epithelium: Location: skin, lining of the mouth, tongue, esophagus, and anus Function: line areas where mechanical stresses are severe Stratified cuboidal epithelium : Location: along the ducts of sweat glands and mammary glands *very rare* Function: secretion Stratified columnar epithelium: Location: along portions of the pharynx, epiglottis, anus, and urethra *very rare* Function: protection

17. © 2013 Pearson Education, Inc. Figure 4-4a Simple Epithelia. Cytoplasm Nucleus Connective tissue Lining of peritoneal cavity LM x 238 Simple Squamous Epithelium LOCATIONS: Epithelia lining ventral body cavities; lining heart and blood vessels; portions of kidney tubules (thin sections of nephron loops); inner lining of cornea; alveoli (air sacs) of lungs FUNCTIONS: Reduces friction; controls vessel permeability; performs absorption and secretion

18. © 2013 Pearson Education, Inc. Figure 4-4b Simple Epithelia. Connective tissue Nucleus Cuboidal cells Kidney tubule LM x 650 Basement membrane LOCATIONS: Glands; ducts; portions of kidney tubules; thyroid gland FUNCTIONS: Limited protection, secretion, absorption Simple Cuboidal Epithelium

19. © 2013 Pearson Education, Inc. Figure 4-4c Simple Epithelia. LM x 350 Microvilli Cytoplasm Nucleus Basement membrane Connective tissue Intestinal lining LOCATIONS: Lining of stomach, intestine, gallbladder, uterine tubes, and collecting ducts of kidneys FUNCTIONS: Protection, secretion, absorption Simple Columnar Epithelium

20. © 2013 Pearson Education, Inc. Figure 4-5a Stratified Epithelia. Stratified Squamous Epithelium Squamous superficial cells Stem cells Basement membrane Connective tissue LM x 310 Surface of tongue LOCATIONS: Surface of skin; lining of mouth, throat, esophagus, rectum, anus, and vagina FUNCTIONS: Provides physical protection against abrasion, pathogens, and chemical attack

21. © 2013 Pearson Education, Inc. Figure 4-5b Stratified Epithelia. Cytoplasm Cilia Nuclei Basement membrane Connective tissue LM x 350 Pseudostratified Ciliated Columnar Epithelium Trachea LOCATIONS: Lining of nasal cavity, trachea, and bronchi; portions of male reproductive tract FUNCTIONS: Protection, secretion, move mucus with cilia

22. © 2013 Pearson Education, Inc. Figure 4-5c Stratified Epithelia. Transitional Epithelium Epithelium (relaxed) Basement membrane Connective tissue and smooth muscle layers LM x 400 Epithelium (stretched) Basement membrane Connective tissue and smooth muscle layers Full bladder Empty bladder Urinary bladder LM x 400 LOCATIONS: Urinary bladder; renal pelvis; ureters FUNCTIONS: Permits expansion and recoil after stretching

23. © 2013 Pearson Education, Inc. Connective Tissue (4-4) Provides a protective structural framework for other tissue types Three basic components 1.Specialized cells 2.Solid extracellular protein fibers 3.Fluid extracellular ground substance

24. © 2013 Pearson Education, Inc. Characteristics of Connective Tissue (4-4) The extracellular components of connective tissues (fibers and ground substance) make up the matrix Majority of tissue volume Determines specialized function

25. © 2013 Pearson Education, Inc. Functions of Connective Tissue (4-4) Support and protection Transportation of materials Storage of energy reserves Defense of the body

26. © 2013 Pearson Education, Inc. Figure 4-7 Major Types of Connective Tissue. CONNECTIVE TISSUES CONNECTIVE TISSUE PROPER FLUID CONNECTIVE TISSUES SUPPORTING CONNECTIVE TISSUES LOOSE DENSE BLOOD LYMPHCARTILAGEBONE Solid, crystalline matrix Solid, rubbery matrix Flows within lymphatic system Flows within cardiovascular system Fibers densely packed Fibers create loose, open framework

27. © 2013 Pearson Education, Inc. Three Major Types of Connective Tissue (4-4) 1.Connective tissue proper 2.Fluid connective tissues 3.Supporting connective tissues

28. Connective tissue proper Consists of: Many cell types Matrix + ground substance Examples: Skin, fatty tissue, tendons, and ligaments © 2013 Pearson Education, Inc.

29. Fluid connective tissue Consists of: Distinct cells in a matrix of water ground substance containing proteins Examples: Blood and lymph © 2013 Pearson Education, Inc.

30. Supporting connective tissue Consists of: Less diverse cell population matrix of dense ground substance and closely packed fibers Examples: Cartilage and bone © 2013 Pearson Education, Inc.

33. Ground Substance (4-4) Clear, colorless, and viscous Fills spaces between cells and slows pathogen movement

34. © 2013 Pearson Education, Inc. Types of Connective Tissue Proper (4-4) Loose connective tissue "Packing materials" of the body More ground substance, fewer fibers Example: fat (adipose tissue) Dense connective tissue Tough, strong, and durable More fibers, less ground substance Example: tendons

35. © 2013 Pearson Education, Inc. Figure 4-8 Cells and Fibers of Connective Tissue Proper. Reticular fibers Fixed macrophage Antibody producing cell Blood in vessel Adipocytes (fat cells) Ground substance Mast cell Elastic fibers Free macrophage Collagen fibers Fibroblast Stem cell White blood cell

36. © 2013 Pearson Education, Inc. Figure 4-9a Loose Connective Tissues. Mast cell Collagen fibers Fat cell Fibroblasts Elastic fibers Macrophage LM x 400 Areolar tissue Areolar Tissue LOCATIONS: Beneath dermis of skin, digestive tract, respiratory and urinary tracts; between muscles; around blood vessels, nerves, and around joints FUNCTIONS: Cushions organs; provides support but permits independent movement; phagocytic cells provide defense against pathogens

37. © 2013 Pearson Education, Inc. Figure 4-9b Loose Connective Tissues. Adipocytes LM x 300 Adipose tissue LOCATIONS : Deep to the skin, especially at sides, buttocks, breasts; padding around eyes and kidneys FUNCTIONS: Provides padding and cushions shocks; insulates (reduces heat loss); stores energy Adipose Tissue

38. © 2013 Pearson Education, Inc. Figure 4-9c Loose Connective Tissues. LOCATIONS: Liver, kidney, spleen, lymph nodes, and bone marrow FUNCTIONS: Provides supporting framework Reticular Tissue Reticular fibers LM x 375 Reticular tissue from liver Reticular tissue

39. © 2013 Pearson Education, Inc. Figure 4-10a Dense Connective Tissues. LOCATIONS: Between skeletal muscles and skeleton (tendons and aponeuroses); between bones or stabilizing positions of internal organs (ligaments); covering skeletal muscles; deep fasciae FUNCTIONS: Provides firm attachment; conducts pull of muscles; reduces friction between muscles; stabilizes relative positions of bones Collagen fibers Fibroblast nuclei Tendon LM x 440 Dense Regular Connective Tissue

40. © 2013 Pearson Education, Inc. Figure 4-10b Dense Connective Tissues. Deep dermis Collagen fiber bundles Dense Irregular Connective Tissue LM x 111 LOCATIONS: Capsules of visceral organs; periostea and perichondria; nerve and muscle sheaths; deep dermis of the skin FUNCTIONS: Provides strength to resist forces applied from many directions; helps prevent overexpansion of organs such as the urinary bladder

41. © 2013 Pearson Education, Inc. Fluid Connective Tissues (4-4) Blood and lymph Watery matrix of dissolved proteins Carry specific cell types (formed elements) Formed elements of blood Red blood cells White blood cells Platelets

42. © 2013 Pearson Education, Inc. Supporting Connective Tissues (4-4) Cartilage Gel-type ground substance For shock absorption and protection Bone Calcified (made rigid by calcium salts, minerals) For weight support

43. © 2013 Pearson Education, Inc. Table 4-3 A Comparison of Cartilage and Bone

44. © 2013 Pearson Education, Inc. Checkpoint (4-4) 12.Identify several functions of connective tissues. 13.List the three types of connective tissues. 14.Which type of connective tissue contains primarily triglycerides? 15.Lack of vitamin C in the diet interferes with the ability of fibroblasts to produce collagen. What effect might this interference have on connective tissue? 16.Which two types of connective tissue have a fluid matrix?

45. © 2013 Pearson Education, Inc. Checkpoint (4-4) 17. Identify the two types of supporting connective tissue. 18. Why does cartilage heal slower than bone?

46. © 2013 Pearson Education, Inc. Tissue Membranes (4-5) Membranes Are physical barriers Line or cover portions of the body Consist of: An epithelium Supported by connective tissues

47. © 2013 Pearson Education, Inc. Four Types of Tissue Membranes (4-5) 1.Mucous membranes 2.Serous membranes 3.Cutaneous membrane 4.Synovial membranes

48. © 2013 Pearson Education, Inc. Figure 4-13 Tissue Membranes. Mucous membranes are coated with the secretions of mucous glands. These membranes line the digestive, respiratory, urinary, and reproductive tracts. Serous membranes line the ventral body cavities (the perito- neal, pleural, and pericardial cavities). The cutaneous membrane, or skin, covers the outer surface of the body. Synovial membranes line joint cavities and produce the fluid within the joint. Mucous secretion Epithelium Lamina propria (areolar tissue) Serous fluid Epithelium Areolar tissue Epithelium Areolar tissue Dense irregular connective tissue Articular (hyaline) cartilage Synovial fluid Capsule Capillary Adipocytes Areolar tissue Epithelium Synovial membrane Bone

49. © 2013 Pearson Education, Inc. Mucous Membranes (4-5) Also known as mucosae Line passageways that have external connections In digestive, respiratory, urinary, and reproductive tracts Epithelial surfaces must be moist To reduce friction To facilitate absorption and excretion Lamina propria Made of areolar tissue

50. © 2013 Pearson Education, Inc. Mucous membranes are coated with the secretions of mucous glands. These membranes line the digestive, respiratory, urinary, and reproductive tracts. Mucous secretion Epithelium Lamina propria (areolar tissue) Figure 4-13a Tissue Membranes.

51. © 2013 Pearson Education, Inc. Serous Membranes (4-5) Line cavities not open to the outside Are thin but strong Have fluid transudate to reduce friction Have a parietal portion covering the cavity Have a visceral portion (serosa) covering the organs

52. © 2013 Pearson Education, Inc. Three Serous Membranes (4-5) 1.Pleura Lines pleural cavities Covers lungs 2.Peritoneum Lines peritoneal cavity Covers abdominal organs 3.Pericardium Lines pericardial cavity Covers heart

53. © 2013 Pearson Education, Inc. Serous membranes line the ventral body cavities (the perito- neal, pleural, and pericardial cavities). Serous fluid Epithelium Areolar tissue Figure 4-13b Tissue Membranes.

54. © 2013 Pearson Education, Inc. The Cutaneous Membrane (4-5) Is skin Covers the surface of the body Thick, waterproof, and dry

55. © 2013 Pearson Education, Inc. The cutaneous membrane, or skin, covers the outer surface of the body. Epithelium Areolar tissue Dense irregular connective tissue Figure 4-13c Tissue Membranes.

56. © 2013 Pearson Education, Inc. Synovial Membranes (4-5) Line moving, articulating joint cavities Produce synovial fluid (lubricant) Protect the ends of bones Lack a true epithelium

57. © 2013 Pearson Education, Inc. Synovial membranes line joint cavities and produce the fluid within the joint. Articular (hyaline) cartilage Synovial fluid Capsule Capillary Adipocytes Areolar tissue Epithelium Synovial membrane Bone Figure 4-13d Tissue Membranes.

58. © 2013 Pearson Education, Inc. Checkpoint (4-5) 19. Identify the four types of tissue membranes found in the body. 20. How does a plasma (cell) membrane differ from a tissue membrane? 21. What is the function of fluids produced by serous membranes? 22. The lining of the nasal cavity is normally moist, contains numerous mucous cells, and rests on a layer of areolar tissue. Which type of membrane is this?

59. © 2013 Pearson Education, Inc. Three Types of Muscle Tissue (4-6) 1.Skeletal muscle tissue Large body muscles responsible for movement 2.Cardiac muscle tissue Found only in the heart 3.Smooth muscle tissue Found in walls of blood vessels Found around hollow organs such as the urinary bladder Around the respiratory, digestive, and reproductive tracts

60. © 2013 Pearson Education, Inc. Functions of Muscle Tissue (4-6) Specialized for contraction Produces all body movement

61. © 2013 Pearson Education, Inc. Cells are long, cylindrical, striated, and multinucleate. LOCATIONS: Combined with connective tissues and neural tissue in skeletal muscles FUNCTIONS: Moves or stabilizes the position of the skeleton; guards entrances and exits to the digestive, respiratory, and urinary tracts; generates heat; protects internal organs Nuclei Muscle fiber Striations Skeletal Muscle Tissue Skeletal muscle LM x 180 Figure 4-14a Muscle Tissue.

62. © 2013 Pearson Education, Inc. Figure 4-14b Muscle Tissue. Cells are short, branched, and striated, usually with a single nucleus; cells are interconnected by intercalated discs. LOCATION : Heart FUNCTIONS: Circulates blood; maintains blood (hydrostatic) pressure Cardiac Muscle Tissue Cardiac muscle Nucleus Cardiac muscle cells Intercalated discs Striations LM x 450

63. © 2013 Pearson Education, Inc. Figure 4-14c Muscle Tissue. Cells are short, spindle-shaped, and nonstriated, with a single, central nucleus. LOCATIONS: Found in the walls of blood vessels and in digestive, respiratory, urinary, and reproductive organs FUNCTIONS: Moves food, urine, and reproductive tract secretions; controls diameter of respiratory passageways; regulates diameter of blood vessels Smooth Muscle Tissue Nucleus Smooth muscle cell Smooth muscle LM x 235

64. © 2013 Pearson Education, Inc. Checkpoint (4-6) 23. Identify the three types of muscle tissue in the body. 24. Voluntary control is restricted to which type of muscle tissue? 25. Which type of muscle tissue has small, tapering cells with single nuclei and no obvious striations?

65. © 2013 Pearson Education, Inc. Neural Tissue (4-7) Also called nervous or nerve tissue Specialized for conducting electrical impulses Rapidly senses internal or external environment Processes information and controls responses

66. © 2013 Pearson Education, Inc. Neural Tissue (4-7) Concentrated in the central nervous system Brain Spinal cord

67. © 2013 Pearson Education, Inc. Two Kinds of Neural Cells (4-7) 1.Neurons Nerve cells Perform electrical communication 2.Neuroglia Supporting cells Repair and supply nutrients to neurons

68. © 2013 Pearson Education, Inc. Cell Parts of a Neuron (4-7) Cell body Contains the nucleus and nucleolus Dendrites Short branches extending from the cell body Receive incoming signals Axon (nerve fiber) Long, thin extension of the cell body Carries outgoing electrical signals to their destination

69. © 2013 Pearson Education, Inc. Axon terminals Brain Spinal cord Cell body Axon Neuron Nuclei of neuroglia Nucleus of neuron Axon Dendrites Cell body LM x 600 Photomicrograph of neuron cell body Figure 4-15 Neural Tissue.

70. © 2013 Pearson Education, Inc. Checkpoint (4-7) 26. A tissue contains irregularly shaped cells with many projections, including some several centimeters long. These are probably which type of cell? 27. Why are both skeletal muscle cells and axons also called fibers?

71. © 2013 Pearson Education, Inc. Tissue Injuries and Repair (4-8) Tissues respond to injuries to maintain homeostasis Cells restore homeostasis with two processes 1.Inflammation 2.Regeneration

72. © 2013 Pearson Education, Inc. Inflammation (4-8) Inflammatory response The tissue's first response to injury Signs and symptoms include: Swelling Heat Redness Pain

73. © 2013 Pearson Education, Inc. Inflammatory Response (4-8) Can be triggered by: Trauma (physical injury) Infection (the presence of harmful pathogens)

74. © 2013 Pearson Education, Inc. Checkpoint (4-8) 28. Identify the two phases in the response to tissue injury. 29. What signs and symptoms are associated with inflammation? 30. What is fibrosis?

75. © 2013 Pearson Education, Inc. Aging Tissue (4-9) With age: Rate of tissue repair declines Cancer rates increase

76. © 2013 Pearson Education, Inc. Aging and Tissue Structure (4-9) Speed and efficiency of tissue repair decrease with age due to: Slower rate of energy consumption (metabolism) Hormonal alterations Reduced physical activity

77. © 2013 Pearson Education, Inc. Aging and Cancer Incidence (4-9) Cancer rates increase with age 1 in 4 people in the United States develops cancer Cancer is the #2 cause of death in the United States Environmental chemicals and cigarette smoke cause cancer

78. © 2013 Pearson Education, Inc. Checkpoint (4-9) 31.Identify some age-related factors that affect tissue repair and structure.