1. Overview Narcolepsy Project By Jessie Y. Shen Wednesday, Oct. 15, 2003

2. Objectives Background on Narcolepsy Project Goals Medical Collaboration Preliminary Results Future Work

3. What is Narcolepsy? Chronic sleep disorder 0.03% to 0.06% of North Americans Loss of REM sleep regulation Disabling and under-diagnosed

4. REM Sleep NON-REM Sleep Physiological Rest REM Sleep Psychological Rest

5. Symptoms of Narcolepsy Excessive daytime sleepiness (EDS) Cataplexy Hypnagogic hallucination Sleep paralysis Automated behavior

6. Treatments Lifestyle Changes Plan naps Medication Stimulants + Antidepressants

7. Effect on Patients Physical hazards Difficulty at school, at work, socially –Academic performance –Work –Social Strained interpersonal relationship due to peer pressure and misunderstanding

8. Problems Fall asleep at inappropriate times Medication’s side effects Plan naps, driving times, etc.

9. Project Goal

10. Design Steps Detection Algorithm Predictive Model Expert System Design Prototype Construction Refinement 1.Channel Selection 2.DSP a.Noise reduction b.Source Separation c.Artifact Removal 3.Dimensionality reduction 4.Classification Detection Algorithm Predictive Model 1.Alertness index 2.Probability a.Alertness b.Sleep attack 3.Verification Expert System Design 1.Waking mechanism 2.Medication allocation 3.Activity planning a.Naps b.Driving c.Meetings Prototype Construction 1.Sensor 2.Processor 3.Waking mechanism 4.GUI Refinement 1.Wireless sensors 2.Conceal sensors 3.Power management 4.Additional features

11. Prototype Detection Algorithm Predictive Model Expert System EEG Acquisition Unit ADC buffer Feature Extraction Classifier DSP User Interface Current Alertness Level Statistics on Future Medication Dosage Activity Plan Wake Mechanism Signal whether patient fell asleep Analog EEG signals Wired connection EEG Segments Alternative Connection Probability of patient’s future alertness RX TX Digital EEG signals Wireless transmission channel Patient’s current alertness

12. Previous Work ANN HMM EEG Awake / Asleep Sleep Stage

13. Collaboration Dr. C. F. P. George –Physician at LHSC –Professor at UWO –Research focus on narcolepsy and performance in sleepy patients

14. References http://www- med.stanford.edu/school/Psychiatry/narcole psy/http://www- med.stanford.edu/school/Psychiatry/narcole psy/ http://www.ninds.nih.gov/health_and_medi cal/disorders/narcolep_doc.htmhttp://www.ninds.nih.gov/health_and_medi cal/disorders/narcolep_doc.htm