1. 6/4/20161 Commitment & Efforts Toward Translational Science Subtitle Placeholder

2. 6/4/20162 To improve the health of our patients & community through innovation & excellence in care, education, research & service. Clarian ’ s Mission- 1997

3. 6/4/20163 To improve the health of our patients & community through innovation & excellence in care, education, research & service. Clarian ’ s Mission- 1997

4. IU Health Research Support Annual support to IUSM for program development and strategic development Hospital partner in CTSI development and operation Alignment of Methodist Research Institute clinical trial unit within CTSI IU Health Values Grants for Research & Education ($1.2 million/year) - focus on young investigators and pilot studies IU-IRB infrastructure/operational support 6/4/2016

5. IUH Research Support, cont’d IU Health Annual Research Pillar Goal 6/4/2016

6. 6 Preeminence Framework

7. 6/4/20167 Preeminence Framework

8. 6/4/20168

9. 9 Total admissions: 135,701 Total OP visits: 2,094,533 Total physicians: 3,707

10. Transformational & Pillar Goals 2014 Transformational Goal: IU Health will be recognized as one of the nation’s leaders in hosting and supporting translational research, and in the development of personalized medicine, & clinical trials/participants across the system. A key requirement will be a robust infrastructure, including IT. 2011 Pillar Goal: Develop & implement system- wide IRB & biobank programs (target: 5375) 6/4/2016

11. Clinical Trials: IT Support For investigators: identification of potential trial candidates. For patients: usable information about available clinical trials For physicians: point-of-service information about potential patient-specific clinical trials 6/4/201611

12. Biorepository patients Mechanism established to allow IU Health submissions prior to completion of system- wide IU IRB (current total 1221) System IU IRB project initial focus on Bloomington, Arnett, Ball. Target to be operational: July 2011. Other IU Health facilities to be engaged on staggered basis. 6/4/2016

13. IUSM-IU Health Joint Strategic Research Planning Enterprise-wide research retreats (2010) Establishment of broad-based Strategic Research Council Development of a major Joint Aligned Strategic Plan for research (2011) Aligned with key strategic service lines Under leadership of David Wilkes, MD, Executive Associate Dean for Research, IUSM 6/4/201613

14. Joint Strategic Research Proposal Cancer Center of Excellence in Cardiovascular Research Neuroscience Research Horizontal programs: IU Health Translational Postdoctoral Scholar Program; Faculty Retention Program. Includes benchmarks, outcomes measures 6/4/201614

15. Cancer Pilot projects Strategic recruitment Statewide Clinical Research Office Center for Chemical Biology and Drug Discovery 6/4/201615

16. Cardiovascular Research Basic and translational research in heart failure Pharmacogenomics to promote drug efficacy and safety Data Coordinating Center for Cardiovascular Outcomes Research 6/4/201616

17. Neuroscience Research Comprehensive Brain Injuries and Insults Research Neurodegenerative Disorders Research Neurodevelopmental Disorders Research 6/4/201617

18. 6/4/2016 Joint Strategic Research Proposal Current Status

19. So...Why is IUH Committed to Enhancing Research? It is a core component of our mission, and aligned with IUSM It is a requisite for providing preeminent quality care for our patients It extends the benefits beyond individuals, to also include the community and the next generation of our citizens and investigators 6/4/2016

20. Thank you