1. Following our way through the Cardiac Cycle:

3. Step by step…

4. Atrial Systole: 20% of ventricular filling
Atria and ventricles at rest
Atrial Systole: 20% of ventricular filling

5. Early ventricular contraction
Obtain first heart sound: AV valves close “lub”
EDV
Isolvolumic ventricular contraction

6. Ventricular relaxation
Our second heart sound:
semilunar valves close
“dup”
ESV
Isovolumetric relaxation
Ventricular Ejection
Ventricular relaxation

7. We’re back to atrial and ventricular relaxation

8. Wiggers Diagram
Ausculation

9. Can we measure how much blood your heart pumps?
CO=SV X Heart Rate

10. What determines our stroke volume?

11. Stroke volume influenced by
Length of muscle fiber
contractility
Frank-Starling Law
(length of muscle fiber)

12. Contractility influence by
Norepinephrine
Drugs: in the news today!
digitalis

14. Blood Pressure and Control of blood pressure
Chapter 15 Blood Flow
Blood Pressure and Control of blood pressure

15. Picture 15-3

16. Then, how then does blood from your extremities get back to heart from these low pressure veins?

17. Skeletal and respiratory pumps

18. Varicose Vein Disorders
Spider Veins
Dr. Berman

19. Measurements of blood pressure
NORMAL BP RANGES
Systolic between 90 and 135 mmHg
Diastolic between 50 and 90 mmHg

20. measures strength of pressure wave
1. Pulse pressure
Systolic pressure-Diastolic pressure
measures strength of pressure wave

21. 2. MEAN ARTERIAL PRESSURE
MAP=1/3 Pulse Pressure + Diastolic pressure
MAP provides a single value that does not show a
all the changes of arterial pressure.

22. Blood Pressure Day 1 Day 2 120/90 160/70
Now by calculating the mean arterial pressure, on which
day is blood flow greatest to the tissues?

23. Local Controllers of Blood pressure
Myogenic autoregulation
Paracrines and smooth muscle

24. Chemical affects on our blood vessels
Norepinepherine
Serotonin NO
Histamine
Epinephrine
Vasocontriction
Vasodilation

25. Migraines: inappropriate vasodilation
Sumatriptan
Serotonin agonist

26. Affect of some paracrines
Active hyperemia
Reactive hyperemia

27. Coordination of blood pressure Control
Baroreceptors stretch
Action potentials to CNS
ANS