1. Governments of the World Present Status Leadership & Commitments New Funding Opportunities

2. PolioPlus: Keep our Promise to Eradicate Polio

3. Progress in Polio Eradication

4. Wild poliovirus Distribution 2007/2008 * Onset of most recent case on 13-Dec-2008 * Onset of most recent case on 13-Dec-2007 2008 2007 # Infected States: 23 W1 (n=111) W3 (n=166) # Infected States: 26 W1 (n=727) W3 (n=70)

5. Key north Nigeria states have almost zero polio despite the outbreak in 2008 (80% of cases are in just 6 states) Polio cases OPV status of children

6. WPV monthly onset by type, with interventions 2006 – 2008 Continuous arrow = National IPDs Broken arrows = Sub-national IPDs tOPVmOPV1 mOPV3

7. WPV3 (n=51) # Infected LGAs: 41 Qter_2’07 # Infected LGAs: 19 WPV3 (n=22) WPV3 (n=35) # Infected LGAs: 31 Distribution of WPV3 infected LGAs by quarter 07/08 # Infected LGAs: 17 WPV3 (n=19) # Infected LGAs: 22 WPV3 (n=26) Qter_3’07Qter_4’07 Qter_1’08 Qter_2’08 # Infected LGAs: 9 WPV3 (n=12) Qter_3’08

8. It is biologically 'easier' to eradicate polio in Nigeria than in India (average number of OPV doses = 4 vs. >8).

9. Uttar Pradesh and Bihar, India

10. Q1 2008* Q3 2008* progress is fragile! * data as on 1 Sept 2008 This year – a historic milestone Technical & tactical innovations beat the most entrenched polio reservoir in India Uttar Pradesh: Last indigenous type 1 polio, Nov 2007 2006

11. WPV1 Polio cases, West UP and Bihar, 2006-08 20062008 * data as on 3 rd January 2009 2007

12. WPV3 Polio Cases, UP and Bihar, 2007-08 20072008 * data as on 3 rd January 2009

13. New Tactics in Endemic Areas Pakistan/Afghanistan Synchronized campaigns since Nov 2006

14. 'Drs. Kakar & Taheri, veterans of the fight against polio, died with their driver in the attack at Kandahar ' Ambitious Afghan polio effort proceeds despite slayings National Post (Canada), 19 Sept 08 Addressing 'suboptimal OPV delivery': heightened resolve in Afghanistan

15. 'I am making polio eradication WHO’s top operational priority. The remaining problems are not technical. They are operational. They can be solved, when we have the resolve.' Dr. Margaret Chan WHO Director-General 17 June 2008

16. World Health Assembly Polio Resolution, 24 May 2008 2) Urges Nigeria to reduce the risk of international spread of poliovirus by quickly stopping the outbreak… 3) Urges India, Pakistan & Afghanistan to implement large-scale mop-ups… A new international resolve to finish eradication.

17. President Karzai Afghanistan New Commitments Head of Government Leadership

18. Pakistan 19 August 2008 "We all have to play our full role to turn the dream of a polio-free Pakistan into reality." Syed Yousuf Raza Gilani Prime Minister, Pakistan

19. Direct advocacy: requesting Head of State assistance on operational challenges Prime Minister India President Nigeria UN Secretary- General

20. Saudi Arabia is further enhancing OPV immunization requirements to protect Pilgrims to Mecca.

22. New ‘Case for Completing Polio Eradication’ 17 May 2007 Polio ‘control’ would cost more than completing eradication

23. Having only routine immunization alone would result in 200,000+ children paralyzed by polio each year. New ‘Case for Completing Polio Eradication’ 17 May 2007

24. New Funding Bill & Melinda Gates Foundation

25. *The terms of the Gates Challenge grant include a small component of funding for research. PolioPlus has not traditionally funded research.

26. PolioPlus: Keep our Promise to Eradicate Polio