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Supplementary table 1 Supplementary table 1. Clinical-pathological features of the resection-only and chemotherapy/resection stage II/III colorectal cancer.

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Presentation on theme: "Supplementary table 1 Supplementary table 1. Clinical-pathological features of the resection-only and chemotherapy/resection stage II/III colorectal cancer."— Presentation transcript:

1 Supplementary table 1 Supplementary table 1. Clinical-pathological features of the resection-only and chemotherapy/resection stage II/III colorectal cancer patient cohorts with mature survival data in the Singapore dataset. A. Composition of two patient groups (N=313), resection-only and chemotherapy/resection. B. Statistical associations between pairs of factors in resection-only and chemotherapy/resection groups. Tests used included Fisher’s Exact test (both categorical factors), Wilcoxon/Kruskal-Wallis tests (categorical and continuous factors) and Spearman rank correlation (both continuous factors). A p-value (Bonferroni correction) of 0.001111 was used to determine significance. Resection-only Resection/Adjuvant Chemotherapy N (n) Age (years, median (range))-69.55 (31.72-96.78)157 (67)59.15 (36.08-80.12)156 (71) GenderMale 68 (27) 85 (41) Female 89 (40) 71 (30) Ethnic groupChinese 137 (61) 136 (62) Non-Chinese 20 (6) 20 (9) Tumour SiteRectal 24 (12) 43 (16) Non-Rectal 133 (55) 113 (55) StageII 114 (44) 51 (22) III 43 (23) 105 (49) Differentiation Group1 4 (1) 5 (3) 2 140 (60) 130 (58) 3 13 (6) 21 (10) Tumour Size (mm, median (range))-4 (0.4-12)157 (67)4 (1-15)156 (71) InvasionNo Invasion 18 (9) 23 (13) Invasion 139 (58) 133 (58) EphA2 LevelLow 76 (24) 82 (38) High 81 (43) 74 (33) Resection-only and Chemotherapy/Resection Cohorts EphA2 Level InvasionDifferentiation Chemotherapy Status Tumour Site (Rectal/ Non-Rectal) EthnicityGenderStageAge Tumour Size EphA2 Level- Invasion0.6174- Differentiation0.59030.1429- Chemotherapy Status0.49830.40740.3139- Tumour Site (Rectal/Non- Rectal) 0.49150.54530.25250.008923- Ethnicity0.09130.44920.012810.1547- Gender0.49840.40240.76500.05480.16880.4986- Stage0.01270.02970.10551.22E-120.27000.86570.6508 Age0.27440.71950.58072.25E-120.10920.16090.00830.1684- Tumour Size0.65270.26730.09170.94290.93710.03820.69530.96180.4226- A. B.

2 Stage I-IV Features Low expression (0-1) (n=255) High expression (2-3) (n=254) Kendall’s tauFisher’s exact p (Bonferroni adjusted) CD440.439<0.001* Low expression19179 High expression64175 LGR50.229<0.001* Low expression10551 High expression150203 CD133 expression-0.0310.526 Low expression150157 High expression10597 Ki-67 expression0.0021.000 Low expression159158 High expression96 AXL expression0.237<0.001* Low expression11961 High expression136193 Supplementary table 2 Supplementary table 2. EphA2 and clinical-pathological correlates in CRC. Correlation between EphA2 and CD44, LGR5, CD133, Ki-67 and AXL in 509 stage I-IV CRC cases of the Singapore dataset.

3 Supplementary table 3 Chemotherapy/ Resection GroupStage EphA2 LevelInvasionDifferentiation Tumour Site (Rectal/non-rectal)EthnicityGenderAge Tumour Size Stage- EphA2 Level0.06014- Invasion0.33550.8218- Differentiation0.3350.5930.4254- Tumour Site (Rectal/non- rectal) 0.45310.85910.31550.5217- Ethnicity0.80310.242110.075230.02899- Gender0.17230.498310.34410.59450.05661- Age0.4420.60560.34480.91950.98730.73240.6121- Tumour Size0.21770.70080.27030.055710.42330.15480.84660.6322- Resection GroupStage EphA2 LevelInvasionDifferentiation Tumour Site (Rectal/non-rectal)EthnicityGenderAge Tumour Size Stage- EphA2 Level0.1541- Invasion0.096890.2142- Differentiation0.40840.49890.1471- Tumour Site (Rectal/non- rectal)0.22560.27410.74060.382- Ethnicity10.23620.25140.082930.7407- Gender0.59220.49830.31610.83890.26930.4767- Age0.0037910.89520.35460.93480.3540.04850.04534- Tumour Size0.25640.79370.70410.71150.36770.15260.71480.4752- A. B. Supplementary table 3. Statistical associations between pairs of factors in the surgery only (A) and surgery/chemotherapy (B) stage II/III groups in the Singapore dataset. Tests used included Fisher’s Exact test (both categorical factors), Wilcoxon/Kruskal-Wallis tests (categorical and continuous factors) and Spearman rank correlation (both continuous factors). A p-value (Bonferroni correction) of 0.00139 was used to determine significance.

4 Supplementary table 4 Supplementary table 4. A. Univariate and multivariate analysis (Cox proportional hazards regression) of resection- chemotherapy stage II/III patient group. B. Final multivariate model (Cox proportional hazards regression) of resection- chemotherapy stage II/III patient group. FACTOR UnivariateMultivariate (Full) N (n)HR95% CIp-valueHR95% CIp-value Age (per year increase) 156 (71)1.031.01-1.050.0013891.031.01-1.060.011000 GenderMale85 (41)1.00 Female71 (30)0.670.4187-1.0760.0977000.630.38-1.040.080000 Ethnic groupChinese136 (62)1.00 Non-Chinese20 (9)1.630.8166-3.3560.1620001.180.51-2.720.710000 Tumour SiteRectal43 (16)1.00 Non-Rectal113 (55)1.070.6107-1.8810.8090001.170.64-2.170.610000 Tumour Size (linear, per year increase) 156 (71)1.171.07-1.290.0011001.151.03-1.270.011000 InvasionNo Invasion133 (58)1.00 Invasion23 (13)1.560.85-2.850.1510001.450.75-2.790.027000 EphA2 LevelLow82 (38)1.00 High74 (33)1.020.64-1.630.9310000.970.59-1.590.910000 Multivariate (Final) N (n)HR95% CIp-value Age (per year increase) 156 (71)1.031.01-1.060.018000 GenderMale85 (41)1 Female71 (30)0.620.38-1.020.060000 Tumour Size (linear, per year increase) 156 (71)1.181.07-1.300.001000 A. B.

5 Supplementary table 5. Statistical association between expression levels of TGF-α and EphA2 using Spearman’s Rank Correlation in GSE17536, GSE39582, GSE14333 and The Cancer Genome Atlas (TCGA). Within each dataset the value of Rho and associated p-value is reported. GSE17536TCGAGSE39582GSE14333 Gene Pairp-valueRhop-valueRhop-valueRhop-valueRho EphA2TGF-α0.0001770.3460721.64E-050.4160859.04E-080.24450.0078830.194794 Supplementary table 5

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