1. Group 4: Integrated Fluorescent Probe and RF Ablator Rachel Riti Alex Walsh

2. What is Radiofrequency Ablation? Minimally invasive Treats small tumors Radiofrequency Waves 1 2

3. Fluorescence What is Fluorescence? 4 Yield vs. Temperature 5-7 8

4. Fiber Optics Fiber Optic Probe – Total Internal Reflection – Flexible – Measures Fluorescence 9 10

5. Current Technology Thermocouples 11

6. Objectives Design a probe capable of both fluorescence measurements and RFA Build the designed probe Test the probe

7. Integration RF Ablator Fiber Optics 3

8. References 1"Radiofrequency Ablation." S. Mark Taper Foundation Imaging Center. Cedars Sinai Health System, 2000.. 2"Ablation of Liver Tumors." The University of Texas M. D. Anderson Cancer Center. 1999.. 3"Laparoscopic radiofrequency ablation therapy (LRFA) for the treatment of hepatocellular carcinoma." Third Department of Internal Medicine. Niigata University School of Medicine, 9 May 2002.. 4Lakowicz, Joseph R. Principles of fluorescence spectroscopy. 3rd ed. Baltimore: Springer Science+Business Media, LLC, 2006. 5Menter, Julian M. “Temperature dependence of collagen fluorescence.” Photochemical and Phtotbiological Sciences. 2006 5, 403-410. 6A. Oliver, G. Baker, R. Fugate, F. Tablin, and J. Crowe, "Effects of Temperature on Calcium-Sensitive Fluorescent Probes," Biophysical Journal, vol. 78, pp 2116-2126, 2000. 7E. Bowen, and J. Sahu. "The Effect of Temperature on Fluorescence of Solutions," Journal of Physical Chemisty, vol. 63, pp 4-7, 1959. 8"Fluorescence." Be Seen On a Bike.. 9"How Fiber Optics Work." Howstuffworks "Electronics.” 09 Nov. 2009.. 10"40 Principles of Invention #2: Taking Out [TRIZ]." Paprika Lab. 25 June 2008.. 11 RITA Medical Systems, “RITA Starburst SDE Electrosurgical Device.” Instructions for Use.