1. A karyotype DAS client DAS workshop 2009 10 th March Rafael Jimenez

2. Visualization of genome data in combination with experimental data and genome analysis helps to formulate testable hypothesis. Eukaryotic Genome browsers specialized to represent annotations on... Specific chromosomes Genome regions in one chromosome Detailed views on genome regions Eukaryotic genome analysis requires visualization in a higher representation level... Full genomic context -> Karyotype Introduction

3. Karyotype DAS client DAS web browser to visualize Eukaryotic genome data at the level of karyotype, chromosome and cytoband. Still a prototype! For more detail views in a lower representation level it interacts with the Ensembl web browser. KaryotypeChromosomeGenome regionDetailed view Karyotype DAS viewer Ensembl

4. Implementation Service broker Service consumer Service provider Service Contract... Interact Publish Find Service Oriented Architecture

5. Registry ClientSources DAS... Publish Find Distributed Annotation System Implementation Interact DAS Registry Genome Analysis Karyotype DAS Client Cromosome Type Ensembl Gene Expression Profile Analysis Suite GPAS Provide

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7. 1 Karyotype Chromosome Genome region Qualitative Quantitative (score) +/- sources by view

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14. 3.1 binning:maxbins

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18. Thank you! Thanks for its support to … Thanks to our collaborators … UCT South Africa CBIO, UCT South Africa … especially for his contribution on this project to … Joaquin Tarraga Bioinfomatics department