1. Ontario Genomics Institute: Overview Christian Burks CBurks@OntarioGenomics.ca www.OntarioGenomics.ca

2. IRC Workshop, 29 Oct ‘05, page 2 Genome Canada

3. IRC Workshop, 29 Oct ‘05, page 3 Ontario Genomics Institute

4. IRC Workshop, 29 Oct ‘05, page 4 Ontario Genomics Institute (OGI) Virtual research institute for genomics and proteomics Not-for-profit corporation, incorporated in 2000 12 full time employees, 3 part-time consultants Located in Toronto, but with an Ontario-wide focus In partnership with: Genome Canada Ontario’s Ministry for Research & Innovation private and public research institutions private finance – individuals and/or institutions

5. IRC Workshop, 29 Oct ‘05, page 5 OGI Focus Building a globally-competitive life sciences industry in Ontario Fund top tier science & technology in genomics & proteomics Fund best organized projects Facilitate & precipitate commercialization Focus on societal impact & outcomes 50% co-funding requirement; international collaborations count!

6. IRC Workshop, 29 Oct ‘05, page 6 General Principles & Practise Fund most inspirational science Fund best organized research 50% co-funding requirement Commercialization can be opportunistically harvested can be lubricated is very difficult to constructively engineer Focus on societal outcomes

7. IRC Workshop, 29 Oct ‘05, page 7 From Central Dogma to Discovery Platforms genes proteins genomics proteomics holistic, high-throughput & systematic approaches to building resources

8. IRC Workshop, 29 Oct ‘05, page 8 OGI R&D Project Portfolio $60M / year R&D project portfolio ~$500M portfolio to date led by Ontario scientists $3M - $30M per program ($12M average) human health, tech development, agriculture, forestry & environment research on associated impact: ethics, education, economic, legal and social 2 “platform” projects: proteomics (PTCF) and genomics (TCAG)

9. IRC Workshop, 29 Oct ‘05, page 9 OGI Science & Technology Platforms The Centre for Applied Genomics (S. Scherer et al.): DNA sequencing, genotyping, and expression arrays >450 users over past year, including Ontario (78%), other Canadian (10%) and other international (12%) users Proteomics Technology Core Facility (G. LaJoie et al.): mass spectrometry >300 users over past year, including private sector (9%) and international (2%) other international users

10. IRC Workshop, 29 Oct ‘05, page 10 Education & Outreach scientists media ReGenesis: “The Facts Behind the Fiction”Engage Modules For High Schools Courtesy of Kevin Siers, The Charlotte Observer © 2001 students and teachers public GEEE! In Genome Suitcase Benchside Consultation Service for Scientists

11. IRC Workshop, 29 Oct ‘05, page 11 Partnering Event Example Symposium: “Stem Cells: Unlocking the Potential” 1-day event, 21 Oct 2005, MaRS Centre (Toronto) Co-hosted by the Stem Cell Network and MaRS National and international speakers Commercialization and scientific presentations

12. Christian Burks CBurks@OntarioGenomics.ca www.OntarioGenomics.ca