1. Global H1N1 pandemic influenza update (Oct 2009) and overview including critical animal-human interface risk factors. Jan Slingenbergh, Senior Officer, Animal Health Service FAO of the UN Rome, Italy slide 1

2. slide 2

3. mallard passerines other ducks anatidae waterbirds domestic ducks and geese other, terrestrial poultry avian - mammalian host barrier pathogen species barrier Influenza type A Influenza type B humans pigs cats prey birds sea mammals horses dogs Host radiation – from generalist to specialist mink ferret slide 3

4. Influenza A host radiation - agricultural encroachment human influenza A H1,3 HPAI H5,7 + H9 / other HA subtypes terrestrial poultry H1, 3 + ? in domestic pigs H1-16 domestic waterfowl wild water bird reservoir H1-16 terrestrial wild birds H1-16 ? H1 ? others? H1H1 H3?H3? H 1,3 HPAI H 5, 7 + H 9 HPAI H 5, 7 + H 9 ? ? H 1,3 H 1 -16 ? ? * * * HPAI H 5 ? H 7 ? H 1 -16 HPAI H 5 H7?H7? H 1 -16 ? * : so far not sustained; spill- over only * slide 4

5. Poultry in the World slide 5

6. Global pre-pandemic influenza alert system RT monitoring of virus evolution in hot-spots of animal-human contact FAO data: losses costs A.H. health protection strategy O/I AGRIPOP / ARALAND. maps of bio-security + health protection regimes FAO pig / poultry flu activity / invasibility proxies FAO/OIE/WHO lab networks sequence data virus evolution WHO related human flu activity monitoring human animal validation geo-spatial analysis risk mapping pig + poultry intensification maps slide 6

7. Poultry in Asia slide 7

8. Poultry in Vietnam (2002) slide 8

9. slide 9

10. slide 10

11. slide 11

12. niches in the disease landscape HPAI in domestic waterfowl slide 12

13. H5N1 niche map slide 13