2. Genetic Repositories Australia BACKGROUND GRA supported by an NHMRC Enabling Facility Grant awarded in 2006.  GRA supported by an NHMRC Enabling Facility Grant awarded in 2006.  Chief Investigators on the NHMRC Enabling Grant are – Professor Peter Schofield (Prince of Wales Medical Research Institute & University of New South Wales) Professor Peter Schofield (Prince of Wales Medical Research Institute & University of New South Wales)  Dr Juleen Cavanaugh (Australian National University, Medical School, Canberra Hospital)  Dr Susan Forrest (Australian Genome Research Facility) Professor John Hopper (Centre for Genetic Epidemiology University of Melbourne) Professor John Hopper (Centre for Genetic Epidemiology University of Melbourne) GRA is based at the Prince of Wales Medical Research Institute in Sydney.  GRA is based at the Prince of Wales Medical Research Institute in Sydney. Facility Manager is Mr Steve Turner.  Facility Manager is Mr Steve Turner.

3. GRA - Aims and Objectives  GRA aims to provide a central national facility for – establishing establishing distributing and distributing and maintaining the long-term secure storage of human genetic samples from a variety of sources. maintaining the long-term secure storage of human genetic samples from a variety of sources.  GRA aims to facilitate world-class collaborative health and medical research in Australia, and internationally through: research in Australia, and internationally through:  the provision of clinically validated but de-identified patient material  complete phenotypic descriptors of disease and family, or cohort structure  permits genetic analyses for disease gene identification.

4. GRA - Services  A central facility for the processing of blood samples and production of B-lymphoblastoid cell lines. of B-lymphoblastoid cell lines.  Extraction of DNA from blood or cell lines.  Samples will be processed from patients, controls and epidemiological participants from studies on a range of diseases and epidemiological participants from studies on a range of diseases and their outcomes. their outcomes.  DNA and immortalized cell lines will be stored for distribution to qualified investigators. qualified investigators.  Samples available for distribution will be processed at a subsidised academic rate. academic rate.  Fee-for-service work can be performed for samples not available for distribution. distribution.

5. GRA FURTHER INFORMATION Mr Steve Turner, Facility Manager (GRA) Prince of Wales Medical Research Institute Randwick, Sydney, Email: gra@unsw.edu.au gra@unsw.edu.au Telephone: (+ 61 2) 9399 1068 Website: www.powmri.edu.au/gra.htm www.powmri.edu.au/gra.htm

6. The ARCBS Aussie Normals 1000 ARCBS blood donors – healthy Caucasians Cell lines & DNA DNA available in 96 well plates from mid April 2007 Biochemical phenotype available via collaboration with researchers (Cavanaugh & Hickman @ ANU) Projects subject to approval by ARCBS

7. AGRF Services SNP Discovery Genotyping Expression analysis