1. 1 Sales of Droperidol Vials to Non-Retail Channels of Distribution 1998 – 2002 IMS Health, National Sales Perspective™, Data Extracted September 2003

2. 2 Purchases of Perioperative Sedation Drugs, 1998 - 2002 IMS Health, National Sales Perspective™, Data Extracted September 2003

3. 3 Purchases of Anti-Emetic Agents, 1998 - 2002 IMS Health, National Sales Perspective™, Data Extracted September 2003

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5. 5 Top PT Terms for Droperidol

6. 6 QT TORSADES (n=22) Indication (single injection, N=12): nausea (n=7); sedation (n=2), anesthesia (n=1); agitation/aggression (n=1); pre-medication (n=1) Procedures (not including aggression) (n=11): spinal column operation, anchilles tendon surgery; urinary bladder lithiasis, urinary tract infection, laparoscopic cholecysectomy, colonoscopy, cardiac telemetry, hepatic shunt replacement, N+V in ER. spinal column operation, anchilles tendon surgery; urinary bladder lithiasis, urinary tract infection, laparoscopic cholecysectomy, colonoscopy, cardiac telemetry, hepatic shunt replacement, N+V in ER.

7. 7 QT TORSADES (n=22) Delta QTc, (msec) (n=5) : 3-5 (n=2); 37-65 (n=2); 100 (n=1) Post-QTc elevations (msec) (n=8): 470-472 (n=3); 490=513 (n=3); >500 (n=1); 500 (n=1) one case pre-600, post 800 (not specified to be corrected) one case pre-600, post 800 (not specified to be corrected) Prior QTc elevation (msec) (n=4): (448, 465, 497, 500 FDA received date (n=22): ‘90=‘96 (n=3); ‘00 (n=1); ‘01 (n=13); ‘02 (n=5) Event date: (n=16); ‘82-’88 (n=3); ‘90-’94 (n=6); ‘95-’98 (n=2); ‘00 (n=1); ‘02 (n=4)

8. 8 QT TORSADES (n=22) Confounding medical hx: yes (cardiac, n=9; drug absuse, n=1) none (n=8); unk (n=5) Concomitant medications: none (n=11); unk (n=9); yes (n=2; levofloxacin, n=1; cyclobenzaprine and fluoxetine interaction, n=1) Least confounded (n=5) foreign (n=4), U.S. (n=1); psych (n=2); N+V (n=1); pre-med (n=1); post-op pain (n=1) foreign (n=4), U.S. (n=1); psych (n=2); N+V (n=1); pre-med (n=1); post-op pain (n=1) Infusion (n=3); one inj (n=2, dose: 12.5 mg and unk) Infusion (n=3); one inj (n=2, dose: 12.5 mg and unk)

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