1. HOW DOES EBOLA EVADE THE IMMUNE SYSTEM? Jessica Lorenzana

2. WHERE DID IT COME FROM?  The Ebola virus outbreak began in 2014  This virus is prominent in humans and non- human primates  Ebola began in African countries such as Sierra Leone, Guinea, and Liberia

3. HOW LETHAL IS IT?  The Ebola virus is a hemorrhagic fever causing the “internal organs into a soup that promptly flows out of the body”  Death rates are as high as 90%  After infection a incubation of 2-21 days will have initial symptoms of high fever and chills  After the incubation period more serious symptoms will appear such as vomiting blood, red eyes due to distention and hemorrhage of sclerotic arteriole  Death from these symptoms is usual in a span of time from 6-16 days

4. HOW DOES THIS HAPPEN?  The Ebola virus is capable of avoiding the immune system, this leaves the body vulnerable to all symptoms  By the time the virus has past its incubation period the immune system will still have not detected the virus or it will be incapable of fighting against the virus  The Ebola protein:VP24, binds to host protein in the body, the job of this protein is to take signaling molecules in and out of the cell nucleus  The VP24 blocks the immune signal that leads to the nucleus, this signal activates the immune system’s anti-viral defenses

5.  The Ebola virus also the ability to hijack the genetic replication machinery of a cell to create more copies of itself  Once the cell has died out the newly formed viruses will exit to infect other cells

6. HOW EBOLA SPREADS?  Ebola is mostly spread through human contact after direct with patients or cadavers of the infected  Ebola outbreaks are mostly located in hospitals due to lack of sanitation  Another form of infection would be from using sanitized needles that have been previously used by the infected

7. LETS REVIEW ! 1. Where did Ebola originate from? 2. what is the mortality rate of the Ebola virus? 3. What are some symptoms of Ebola? 4. How does the Ebola virus leave the body vulnerable? 5. How does the Ebola virus prevent the immune system from detecting it? 6. How does the Ebola virus spread thought the body?

9. BIBLIOGRAPHY  http://news.wustl.edu/news/Pages/27218.aspx http://news.wustl.edu/news/Pages/27218.aspx  https://microbewiki.kenyon.edu/index.php/Infection_Mechanism_of_Ge nus_Ebolavirus https://microbewiki.kenyon.edu/index.php/Infection_Mechanism_of_Ge nus_Ebolavirus  http://www.nasw.org/users/mslong/2010/2010_09/Ebola.htm http://www.nasw.org/users/mslong/2010/2010_09/Ebola.htm