1. Discovery of 4 common SNPs in the human tyrosine hydroxylase (TH) proximal promoter Figure 1. Discovery of four common SNPs (with flanking sequences) in the human tyrosine hydroxylase (TH) proximal promoter. A, C-824T (C/C C/T, T/T); B, G-801C (G/G, G/C, C/C); C, A-581G (A/A, A/G, G/G); D, G-494A (G/G, G/A, A/A). Red arrows indicate the SNP positions. Results are ABI-3100 sequence tracings analyzed in PolyPhred. C-824T A-581G G-801C G-494A Online I

2. Online II

3. Human tyrosine hydroxylase (TH) promoter: Graphical Observation of Linkage Disequilibrium (“GOLD”). 4 common SNPs (minor allele freq. 0.119-0.454) spanning 331 bp. Results by Lian Zhang in n=293 unrelated individuals of four different ancestries. 1-3-05. D’ Promoter position 5’ of ATG Online IIIA

4. Human tyrosine hydroxylase (TH) promoter: Graphical Observation of Linkage Disequilibrium (“GOLD”). 4 common SNPs (minor allele freq. 0.119-0.484) spanning 331 bp. Results by Lian Zhang in n=189 unrelated individuals of European ancestry. 1-3-05. D’ Promoter position 5’ of ATG Online IIIB

5. Human tyrosine hydroxylase (TH) promoter: Graphical Observation of Linkage Disequilibrium (“GOLD”). 4 common SNPs (minor allele freq. 0.100-0.283) spanning 331 bp. Results by Lian Zhang in n=30 unrelated individuals of Asian ancestry. 1-3-05 D’ Promoter position 5’ of ATG D’ Online IIIC

6. Human tyrosine hydroxylase (TH) promoter: Graphical Observation of Linkage Disequilibrium (“GOLD”). 4 common SNPs (minor allele freq. 0.171-0.471) spanning 331 bp. Results by Lian Zhang in n=35 unrelated individuals of Hispanic ancestry. 1-3-05. D’ Promoter position 5’ of ATG Online IIID

7. Human tyrosine hydroxylase (TH) promoter: Graphical Observation of Linkage Disequilibrium (“GOLD”). 4 common SNPs (minor allele freq. 0.090-0.410) spanning 331 bp. Results by Lian Zhang in n=39 unrelated individuals of African ancestry. 1-3-05. D’ Promoter position 5’ of ATG Online IIIE

8. Online IVA Baroreceptor slope: Downward versus upward deflections.

9. TH pleiotropy. Baroreceptor sensitivity as a determinant of basal norepinephrine release. Stratification by TH promoter haplotype 2. Downward deflections. Online IVB