1. ANTIBIOTICS AND DRUGS

3. The Sites of Activity in a Bacterial Cell for Various Antibiotics

4. The history of chemotherapy starts with Paul Ehrlich Development of salvarsan to treat syphilis

5. The Disruption of Folic Acid Synthesis by Competitive Inhibition

6. Antibiotics

7. The first Drug to be developed for use in WW2 was Sulfa.

8. Sulfanilamide and other sulfonamides interfere with metabolic reactions Competitive inhibition are drugs as synthesized in lab

9. The discovery of antibiotics began with Fleming Lysozyme Penicillin Florey and Chain

10. Alexander Fleming

11. Fleming’s Lab

12. Penicillin discovered

13. Mold inhibiting Staph

14. Penicillin first used in World War 2

15. Destruction of bacteria by antimicrobials

16. Effects of a Beta Lactam antibiotic on a cell

17. Antimicrobials that interfere with Cell wall synthesis

18. All the derivatives from Penicillin G

19. Penicillin inhibits bacterial cell wall synthesis Beta-lactam nucleus

20. Semisynthetic Penicillins

21. Role of Penicillinase

22. The Action of Penicillinase on Sodium Penicillin G

23. Cephalosporins also inhibit cell wall synthesis Resemblance to penicillins Generations of cephalosoporin

24. Structure of cephalosporin and penicillin

25. Antimicrobials that inhibit protein synthesis

26. How Drug Resistance can Occur

27. Tetracyclines, aminoglycosides, erythromycins, clindamycins are another group of drugs that affect protein synthesis

28. Antimicrobial assays Different methods to evaluate the effectiveness of an antimicrobial

29. Kirby Bauer Disk Diffusion Test

30. Determining the MIC of an antimicrobial

31. MIC dilution tests

32. E-Test

33. Common mechanisms of drug resistance by bacteria

34. Selective advantage of drug- resistance in a population

35. How Drug Resistance can Occur

36. Antibiotics have been misused and abuse Evolving resistance in bacteria Antibiotic misuse and abused  Society  Hospitals  Livestock feeds

37. Genome of a Mycoplasma