1. Human Brain and Behavior Laborator y

4. Mathematics Chemistry Biomedical science Psychology Physics Biology Engineering Philosophy Complexity

5. Time-dependent description of their coordination time Time-dependent description of the components

6. time

9. Adapted from Gray, König, Engel & Singer, 1989

10. “synchronized” – rhythm is regular – amplitude is large – observed during idling “desynchronized” – rhythm is irregular – small amplitude – observed during engaged cognitive states

11. Desynchronized No integrative percept Synchronized Integrative percept Idling Synchronized Alert Desynchronized

16. Galuske et al

19. Too much coordination (epilepsy) Cognition Too little coordination (schizophrenia, autism etc…) segregation integration information

20. Kelso et al., 1990 Bressler and Kelso, 2001 Kelso &Tognoli, 2007 Tognoli & Kelso, 2009  =  - a sin  - 2b sin (2  ) +  Q  t

21. time (phase of one oscillator)

22. If rp t =rp t+1 =rp t+2… Oscillations are phase-locked time

23.  =  - a sin  - 2b sin (2  ) +  Q  t If rp t =rp t+1 =rp t+2… Oscillations are phase-locked Kelso et al., 1990 Bressler and Kelso, 2001 Kelso &Tognoli, 2007 Tognoli & Kelso, 2009

24. Advantages? 1.Coordination extended to a larger range of components 2.Speed: no need for a disengagement mechanism (phase scattering) 3.Flexibility: a series of attracting tendencies can be visited dynamically over the time course of the Coordination Variable 4. Balance integration~segregation: situates the system in the range of maximal information Advantages? 1.Coordination extended to a larger range of components 2.Speed: no need for a disengagement mechanism (phase scattering) 3.Flexibility: a series of attracting tendencies can be visited dynamically over the time course of the Coordination Variable 4. Balance integration~segregation: situates the system in the range of maximal information Why? Brain is a complex nonlinear system Key features: patterned connectivity (locally dense, remotely sparse and selective) Symmetry breaking: -Heterogeneity of the coordinating elements: different intrinsic frequencies -Heterogeneity of their coupling

27. With Bernier, Murias et al. imitation behavior in autistic adults Tognoli & Kelso, in prep

30. Benites et al., in prep 4d dynamical analysis of continuous EEG is key to recognize real synchrony

31. Information transfer (Shannonian theory) Information transfer (Shannonian theory) Linearly coupled oscillations (Hebbian assemblies theory) Linearly coupled oscillations (Hebbian assemblies theory)

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