2.  BSA (m 2 ) = √ Ht(in) X wt (lb) 3131 Ht (cm) X wt (kg) 3600 Mosteller,RD " Simplified Calculation of Body Surface Area", N Engl J Med 1987, 317 (17): 1098 (letter)

3.  Case Example:  Female patient; weight 163 lb, Height 5’5”  On regimen:  Doxorubicin 40-60m 2 I.V ( DAY 1)  Cyclophosphamide 600mg/ m 2 I.V  Followed By:  Paclitaxel 175mg/m 2 IV over 3 hours  Repeat every 21 days for four cycles

4.  √  1.839 1.84m 2 is BSA  40mg X 1.84 m 2 = 73.6mg  600mg X 1.84 m 2 = 1104mg  175mg X 1.84m 2 = 322mg 65 X 163 3131

5.  Trastuzumab- given following completion of anthracycline therapy  Initial loading dose 8mg/kg infused over 90 minutes  Maintenance dose 6 mg/kg infused over 30- 90 minutes every three weeks for total therapy duration of 52 weeks

6.  Pt weight is 163 lb  1kg= 2.2lb  163lb = 73.9 kg 2.2 8mg X 73.9 = 591.2mg ( as loading dose infused over 90 minutes) 6mg X 73.9 = 443.4mg ( as maintenance dose infused over 30 to 60 minutes every three weeks)

7.  Monitoring Parameters!!!  CBC with differential  Platelet count  Liver function tests ( bilirubin, AST, ALT, alkaline phosphatase)  Cardiac function ( baseline, periodic and follow up) ECG, Left Ventricular ejection Fraction