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Growth Hormone Treatment in Children with Malignant Cranial Tumours in KIGS Michael B Ranke and David A Price KIGS 10 Year Book, 1999.

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Presentation on theme: "Growth Hormone Treatment in Children with Malignant Cranial Tumours in KIGS Michael B Ranke and David A Price KIGS 10 Year Book, 1999."— Presentation transcript:

1 Growth Hormone Treatment in Children with Malignant Cranial Tumours in KIGS Michael B Ranke and David A Price KIGS 10 Year Book, 1999

2 Michael B Ranke - KIGS 10 Year Book, 1999 Auxological characteristics of KIGS patients with CNS tumours near the pituitary region MPH, mid-parental height; WHI, weight-for-height index; SDS, standard deviation scores (1/6)

3 Michael B Ranke - KIGS 10 Year Book, 1999 MPH, mid-parental height; WHI, weight-for-height index; SDS, standard deviation scores Auxological characteristics of KIGS patients with CNS tumours near the pituitary region (2/6)

4 Michael B Ranke - KIGS 10 Year Book, 1999 MPH, mid-parental height; WHI, weight-for-height index; SDS, standard deviation scores Auxological characteristics of KIGS patients with CNS tumours near the pituitary region (3/6)

5 Michael B Ranke - KIGS 10 Year Book, 1999 MPH, mid-parental height; WHI, weight-for-height index; SDS, standard deviation scores Auxological characteristics of KIGS patients with CNS tumours near the pituitary region (4/6)

6 Michael B Ranke - KIGS 10 Year Book, 1999 MPH, mid-parental height; WHI, weight-for-height index; SDS, standard deviation scores Auxological characteristics of KIGS patients with CNS tumours near the pituitary region (5/6)

7 Michael B Ranke - KIGS 10 Year Book, 1999 MPH, mid-parental height; WHI, weight-for-height index; SDS, standard deviation scores Auxological characteristics of KIGS patients with CNS tumours near the pituitary region (6/6)

8 MPH, mid-parental height; WHI, weight-for-height index; SDS, standard deviation scores Michael B Ranke - KIGS 10 Year Book, 1999 Auxological characteristics of KIGS patients with CNS tumours distant from the pituitary region (1/6)

9 MPH, mid-parental height; WHI, weight-for-height index; SDS, standard deviation scores Michael B Ranke - KIGS 10 Year Book, 1999 Auxological characteristics of KIGS patients with CNS tumours distant from the pituitary region (2/6)

10 MPH, mid-parental height; WHI, weight-for-height index; SDS, standard deviation scores Michael B Ranke - KIGS 10 Year Book, 1999 Auxological characteristics of KIGS patients with CNS tumours distant from the pituitary region (3/6)

11 MPH, mid-parental height; WHI, weight-for-height index; SDS, standard deviation scores Michael B Ranke - KIGS 10 Year Book, 1999 Auxological characteristics of KIGS patients with CNS tumours distant from the pituitary region (4/6)

12 MPH, mid-parental height; WHI, weight-for-height index; SDS, standard deviation scores Michael B Ranke - KIGS 10 Year Book, 1999 Auxological characteristics of KIGS patients with CNS tumours distant from the pituitary region (5/6)

13 MPH, mid-parental height; WHI, weight-for-height index; SDS, standard deviation scores Michael B Ranke - KIGS 10 Year Book, 1999 Auxological characteristics of KIGS patients with CNS tumours distant from the pituitary region (6/6)

14 Michael B Ranke - KIGS 10 Year Book, 1999 Pituitary deficits in KIGS patients with CNS tumours

15 Michael B Ranke - KIGS 10 Year Book, 1999 Chronological age (years) at onset of puberty in adolescents with CNS tumours

16 Michael B Ranke - KIGS 10 Year Book, 1999 Auxological characteristics of KIGS patients from tumour subgroups MPHD, multiple pituitary hormone deficits; m, male; f, female; WHI, weight-for-height index; SDS, standard deviation scores (1/8)

17 Michael B Ranke - KIGS 10 Year Book, 1999 Auxological characteristics of KIGS patients from tumour subgroups MPHD, multiple pituitary hormone deficits; m, male; f, female; WHI, weight-for-height index; SDS, standard deviation scores (2/8)

18 Michael B Ranke - KIGS 10 Year Book, 1999 Auxological characteristics of KIGS patients from tumour subgroups MPHD, multiple pituitary hormone deficits; m, male; f, female; WHI, weight-for-height index; SDS, standard deviation scores (3/8)

19 Michael B Ranke - KIGS 10 Year Book, 1999 Auxological characteristics of KIGS patients from tumour subgroups MPHD, multiple pituitary hormone deficits; m, male; f, female; WHI, weight-for-height index; SDS, standard deviation scores (4/8)

20 Michael B Ranke - KIGS 10 Year Book, 1999 Auxological characteristics of KIGS patients from tumour subgroups MPHD, multiple pituitary hormone deficits; m, male; f, female; WHI, weight-for-height index; SDS, standard deviation scores (5/8)

21 Michael B Ranke - KIGS 10 Year Book, 1999 Auxological characteristics of KIGS patients from tumour subgroups MPHD, multiple pituitary hormone deficits; m, male; f, female; WHI, weight-for-height index; SDS, standard deviation scores (6/8)

22 Michael B Ranke - KIGS 10 Year Book, 1999 Auxological characteristics of KIGS patients from tumour subgroups MPHD, multiple pituitary hormone deficits; m, male; f, female; WHI, weight-for-height index; SDS, standard deviation scores (7/8)

23 Auxological characteristics of KIGS patients from tumour subgroups MPHD, multiple pituitary hormone deficits; m, male; f, female; WHI, weight-for-height index; SDS, standard deviation scores Michael B Ranke - KIGS 10 Year Book, 1999 (8/8)

24 Response to GH treatment compared with predicted height velocity (cm/year) shown as studentised residuals for the first prepubertal year for patients with CNS tumours distant from the pituitary basedon the KIGS prediction model for idiopathic GHD Michael B Ranke - KIGS 10 Year Book, 1999 Predicted height velocity (cm/year) Studentised residuals (1/2)

25 Michael B Ranke - KIGS 10 Year Book, 1999 Response to GH treatment compared with predicted height velocity (cm/year) shown as studentised residuals for the first prepubertal year for patients with medulloblastoma based on the KIGS prediction model for idiopathic GHD Studentised residuals Predicted height velocity (cm/year) (2/2)

26 Comparison of final height data of patients with germinoma and medulloblastoma Michael B Ranke - KIGS 10 Year Book, 1999 MPHD, multiple pituitary hormone deficits; m, male; f, female; MPH, mid-parental height; SDS, standard deviation scores (1/4)

27 Comparison of final height data of patients with germinoma and medulloblastoma Michael B Ranke - KIGS 10 Year Book, 1999 MPHD, multiple pituitary hormone deficits; m, male; f, female; MPH, mid-parental height; SDS, standard deviation scores (2/4)

28 Comparison of final height data of patients with germinoma and medulloblastoma Michael B Ranke - KIGS 10 Year Book, 1999 MPHD, multiple pituitary hormone deficits; m, male; f, female; MPH, mid-parental height; SDS, standard deviation scores (3/4)

29 Comparison of final height data of patients with germinoma and medulloblastoma Michael B Ranke - KIGS 10 Year Book, 1999 MPHD, multiple pituitary hormone deficits; m, male; f, female; MPH, mid-parental height; SDS, standard deviation scores (4/4)


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