1. 1 Predicting the Chronic Effects of PAHs using the Target Lipid Model of Narcotic Toxicity Joy McGrath Dominic Di Toro HydroQual, Inc. SETAC North America 27 th Annual Meeting Montreal, Canada November 5-9, 2006

2. 2 Acknowledgement Funding for this project was provided by the Coastal Response Research Center www.crrc.unh.edu

3. 3 Acute Toxicity QSARs for Narcotics

4. 4 Computation of Effect Concentrations

5. 5 Acute Effects (lethality) – Single Exposures Water ColumnSediment

6. 6 Chronic Effects (Growth, Reproduction, Mortality) – Single Exposures

7. 7 Water Column – Chronic Sublethal Effects

8. 8 90% Confidence Limits in Predicted Effect Concentration

9. 9 Water Column – Other Chronic Sublethal Effects - PAH Mixtures Rhodes et al, 2005

10. 10 HC5 Values for Water and Sediment

11. 11 Comparison of HC5s and NOECs for PAHs WATERSEDIMENT