1. WHO Collaborating Centre for Influenza - Australia

2. Influenza in Australia 1992 - 2000

3. Influenza in New Zealand

4. Monthly distribution of influenza isolates Thailand 2000

5. Source of Virus Isolates Analysed Jan 2000 - Jan 2001 Australia Malaysia New Caledonia New Zealand Philippines Singapore South Africa Thailand Taiwan Vietnam

6. Distribution of Types/Subtypes Jan 2000 - Jan 2001 A(H3N2) A(H1N1) B 13.8% 59.5% 26.8% 41.1% 36.8% 22.2% 53.1% 26.2% 20.7% 46.3% 41.5% 12.2% Australia New Zealand Other Asia

7. Influenza A(H1) Analysis (1)

8. Influenza A(H1) Analysis (2)

9. Antigenic Analysis of A(H1N1) Isolates Jan - Aug 2000Sept 2000 - Jan 2001

10. Influenza A(H1N1) Isolates HA1 Sequence Analysis

11. Influenza A(H1N1) Isolates NA Sequence Analysis

12. Influenza A(H3) Analysis ANTISERUM ABCDEFHuman Sera Pool PassageSampleDate REF. Ag SYD/5MOS/10PAN/2007TEHRANSYD/203ULAN A A/SYDNEY/5/97 640 640640640128064080CEK2,E5 B A/MOSCOW/10/99320 >2560 64064012801280160E7 C A/PANAMA/2007/998040 640 16016064040E7 D A/TEHRAN/14/99160640640 1280 1280128080X2,E3 E A/SYDNEY/203/20006401280640640 >2560 128080E4 F A/ULAN/UDE/01/200032080320640320 1280 80E6 TEST Ag A/VICTORIA/346/20003201280640640640640160X,MD1 A/WELLINGTON/13/20008032032032032032040MDX,MD1 A/WAIKATO/7/2000640128064012801280128080MDX,MD1 A/WAIKATO/10/2000320128012801280>25601280160MEKX,MD1 A/WAIKATO/14/2000640128012801280>2560>2560320MDX,MD1 A/WAIKATO/15/200032064064064064064080MEKX,MD1 A/WAIKATO/17/200040160801608080<20MEKX,MD1 A/STH AUST/101/2000 4016016016016016020MDX,MD128.09.00 A/STH AUST/136/2000 1606406401280128032040MDX,MD111.10.00 A/BRISBANE/71/200080160160160160160<20MDX,MD120.09.00 A/BRISBANE/72/200080640640640128032040MDX,MD123.09.00 A/BRISBANE/75/20008016016032032032020MDX,MD103.10.00

13. Antigenic Analysis of A(H3N2) Isolates A/Sydney 5.9% A/Sydney (low) 12.3% A/Moscow 67.8% A/Moscow (low) 14.0% A/Moscow 62.5% A/Moscow (low) 37.5% Jan - Aug 2000Sept 2000 - Jan 2001

14. Influenza A(H3N2) Isolates HA1 Sequence Analysis

15. Influenza A(H3N2) Isolates NA Sequence Analysis

16. Influenza B Analysis (1)

17. Influenza B Analysis (2) ANTISERUM PASSAGE ABCDE BEIJ/184YAM/166SICH/379B/JOH/5VIC/504 REF. Ag A B/BEIJING/184/93 320 320640640320E10 B B/YAMANASH/166/98320 320 1280320160E11 C B/SICHUAN/379/99160160 640 320320E9 D B/JOHANNESBURG/5/993203201280 320 320E5 E B/VICTORIA/504/200080<20160160 320 CEK1E1 TEST Ag B/C’CHURCH/22/200016040640320640MD302.10.00 B/VICTORIA/114/200016080640320640MDX,MD126.09.00 B/VICTORIA/107/200016020320160320MKX,MD116.08.00 B/WELLINGTON/21/200016040640320640MD227.09.00 B/BRISBANE/30/200016040640320640MDX,MD119.09.00 B/BRISBANE/38/200032080640320320MDX,MD125.09.00 B/STH AUST/85/2000 80<20160160320MDX,MD107.09.00 B/STH AUST/86/2000 8020320160320MDX,MD107.09.00 B/VICTORIA/321/200080<20320160640X,MD112.09.00 SAMPLE DATE DATE

18. B/Shangdong 6.7% B/Beijing 90.5% B/Sichuan 2.9% B/Beijing 60.3% B/Sichuan 39.7% Antigenic Analysis of Type B Isolates Jan - Aug 2000Sept 2000 - Jan 2001

19. 0246

20. Influenza B Isolates NA Sequence Analysis

21. New Cal/20/99 Auck/32/2000 Joh/82/96 Texas/87/2000 Wuhan/292/2000 USA GMTUSA >40Aust GMTAust >40 0 100 200 300 400 Influenza Type A(H1N1) Vaccine Responses - Older Adults 2000

22. Influenza Type A(H3N2) Vaccine Responses - Older Adults 2000 USA GMTUSA >40Aust GMTAust >40 0 20 40 60 80 100 120 140 160 Sydney/5/97 Panama/2007/99 Tehran/14/99 Sydney/203/2000 Ulan Ude/1/2000 VBrazil/991/2000 Fujian/40/2000 Hong Kong/1923/2000 Lyon/1242/2000

23. Influenza Type B Vaccine Responses - Older Adults 2000 Yamanashi/166/98 Joh/5/99 Sichuan/379/99 Auckland/1/2000 Christchurch/2/2000 Zagreb/3578/99 Victoria/504/2000 Alaska/16/2000 Series 9 USA GMTUSA >40Aust GMTAust >40 0 20 40 60 80 100 120