1. MON 4/29 wk-6 OBJECTIVE: 9-10 TOPIC: gene mutations DO NOW :  daily grade: -12.4 READ-APP/Qs AGENDA: WRAP UP :  DW: -13.2 PRE-LABDUE: TUES  -WK#5 OBJECTIVE QUIZ - 12.4 READ Qs -12.4 VIDEO: Birth and Death of Genes  MON: -GATTACA Qs -wk #5 org/OBJ QUIZ  ABSENT--  HANDOUTS: -weekly organizer -13.2 READ Qs  COMPLETE & TURN IN: -GATTACA Qs -wk #5 ORG/OBJ QUIZ BEFORE/AFTER SCHOOL: -DW check—12 materials -LIST processes that cause mutations -mutation… A:-permanent change in DNA general/honors

2. WEEK #5 OBJ QUIZ

3. 6- During transcription __________________. a. DNA is replicated b. mRNA is produced c. proteins are synthesized 7-What is the end result of translation? a. nucleotides form chains to make amino acids b. mRNA send the message to the ribosomes c. proteins are created from chains of amino acids

4. WEEK #5 OBJ QUIZ 8- Which of the following sequences of processes correctly reflects the central dogma? a.protein synthesis, transcription, translation b.transcription, translation, protein synthesis c.translation, transcription, protein synthesis

5. WEEK #5 OBJ QUIZ MATCHING Match the parts in the diagram with the correct label ____9- contains genetic information a. DNA only ____10- contains ribose b. RNA only ____11- found in nucleus onlyc. both DNA and RNA

6. 12.4 GENE REGULATIONS and MUTATIONS  WHAT YOU WILL LEARN -prokaryotic/eukaryotic gene regulation -types of mutations & results -mutagens

7. READING Q’s 1-Like DNA code, the following sentence: “The dog ran” contains only 3 letter words -INSERT a “z” after “Th”—rewrite the sentence: Thz edo gra -WRITE the sentence again inserting an additional letter Thz zed ogr -What happens to the sentences as you add letters? become nonsense

8. READING Q’s 2-DESCRIBE point mutation -single nucleotide/base pair is changed can cause a genetic disorder

9. READING Q’s 3-NAME -what type of mutation occurs when a STOP codon replaces an amino acid codon -nonsense mutation cause translation to terminate early proteins cannot function normally

10. READING Q’s 4-EVALUATE -Would a 3-nucleotide insertion result in a frameshift?  YES  NO -EXPLAIN -insertion of a nucleotide shifts an entire 3 code sequence—shifts amino acid sequence X

11. READING Q’s 5-RECORD The mRNA sequence/sub A for G -AUG–AAG–UUU–GGC – ACA – UUG-UAA

12. READING Q’s 6-COMPLETE table: frameshift / substitution -substitution -frameshift

13. READING Q’s 7-EXPLAIN how UV light damages DNA -links thymines—forms a “kink”

14. READING Q’s 8-DETERMINE -what a mutation can do to a body (somatic) cell -cell death -cancer cell

15. READING Q’s 9-DISCUSS why a mutagen can have longer lasting effects in a sex cell than a body cell -mutations in sex cells are passed on to their offspring -mutations in body cells are not inherited