1. New extramural projects funded by MF Aubrey D.N.J. de Grey, Ph.D. Chairman and CSO, Methuselah Foundation Lorton, VA, USA and Cambridge, UK Email: aubrey@sens.org Website: http://www.mfoundation.org/http://www.mfoundation.org/

2. The good news, 1/1/09: still the old familiar table Damage rising with ageIt or its effects reversible by Cell loss, cell atrophyCell therapy, mainly Extracellular junkPhagocytosis by immune stimulation Extracellular crosslinksAGE-breaking molecules/enzymes Death-resistant cellsSuicide genes, immune stimulation Mitochondrial mutationsAllotopic expression of 13 proteins Intracellular junkTransgenic microbial hydrolases Nuclear [epi]mutations (only cancer matters) Telomerase/ALT gene deletion plus periodic stem cell reseeding

3. The bad news, 1/1/08 Damage rising with ageIt or its effects reversible by Cell loss, cell atrophyCell therapy, mainly Extracellular junkPhagocytosis by immune stimulation Extracellular crosslinksAGE-breaking molecules/enzymes Death-resistant cellsSuicide genes, immune stimulation Mitochondrial mutationsAllotopic expression of 13 proteins Intracellular junkTransgenic microbial hydrolases Nuclear [epi]mutations (only cancer matters) Telomerase/ALT gene deletion plus periodic stem cell reseeding Blue: MF funded from 2006 Red: MF-funded since 2006 Black: not MF-funded, 1/1/08

4. The good news, 1/1/08

5. The good news, 1/1/09 Damage rising with ageIt or its effects reversible by Cell loss, cell atrophyCell therapy, mainly Extracellular junkPhagocytosis by immune stimulation Extracellular crosslinksAGE-breaking molecules/enzymes Death-resistant cellsSuicide genes, immune stimulation Mitochondrial mutationsAllotopic expression of 13 proteins Intracellular junkTransgenic microbial hydrolases Nuclear [epi]mutations (only cancer matters) Telomerase/ALT gene deletion plus periodic stem cell reseeding Blue: MF funded from 2006 Red: MF-funded since 1/1/2008 Black: not MF-funded, 1/1/09

6. The new projects - Janko Nikolich-Zugich: two-part immune rejuvenation - Jan Vijg: epimutations in the cerebral cortex - The Gavrilovs: demographic consequences of SENS - Lenhard Rudolph: telomerase-negative blood (imminent)

7. What can YOU do in univ. labs? Well, if you’re an undergraduate… http://www.mfuri.org/

8. How it works Within universities in the United States, students can perform independent research (typically lab projects in the form of advanced honors research projects). There is no cost for the student, but they must find a campus faculty member whose lab they may work in. By default, the successful approval of any student project brings onboard a full research lab and PhD mentor at no cost. Using this mechanism, MFURI utilizes undergraduate students to perform research to benefit the SENS agenda. As a way to generate student interest, MFURI has developed a lucrative scholarship program. Grants are also provided to cover basic costs of the lab work such as disposables and other necessary equipment/materials. kelsey.moody@mfoundation.org

9. The bad news, 1/1/09 Damage rising with ageIt or its effects reversible by Cell loss, cell atrophyCell therapy, mainly Extracellular junkPhagocytosis by immune stimulation Extracellular crosslinksAGE-breaking molecules/enzymes Death-resistant cellsSuicide genes, immune stimulation Mitochondrial mutationsAllotopic expression of 13 proteins Intracellular junkTransgenic microbial hydrolases Nuclear [epi]mutations (only cancer matters) Telomerase/ALT gene deletion plus periodic stem cell reseeding Blue: MF funded from 2006 Red: partly MF-funded since 1/1/2008 Black: not MF-funded, 1/1/09

10. More bad news, 1/1/09