1. Antiviral Drugs

3. Mechanism of Action Picornaviruses eg, polioviruses, cold viruses Block attachment molecule on host cell or pathogen Attachment antagonists arildone Influenza A virus Prevents viral uncoating Inhibit viral uncoating Amantadine, rimantadine

4. Mechanism of Action (cont.) Herpes, Epstein Barr, CMV, Varicella RSV, HCV, Influenza A, hemorrhagic fever viruses Phosphorylation by virus encoded protein kinase activates the drug to inhibit DNA & RNA synthesis Inhibit nucleic acid synthesis * Acyclovir * Ganciclovir * Ribavirin

5. Mechanism of Action (cont.) Herpes virus HIV Phosphorylation by cell encoded protein kinase activates the drug to inhibit DNA synthesis Inhibit nucleic acid synthesis * Adenosine arabinoside *Nucleoside analogs (azidothymidin e

6. Nucleoside analogues

7. Mechanism of Action (cont.) Inhibit viral proteins * Protease inhibitors blocks the active HIV site