1. Why Trials managers are Important Peter Davidson Director NETSCC, HTA

2. NHS Research community HTA programme The HTA programme Ensuring that high quality information about the costs, effectiveness and broader impact of health technologies is produced in the most efficient way for those who use, provide care in, make policy for and manage the NHS

3. Successful trials ►Relevant ►Trustworthy ►Clearly reported ►Timely ►Value for money ►safe for participants

4. BMJ Paper of the Year 2011

5. CRASH2

6. Stages in a trial ►Planning and design ►Application for funding ►Conducting the trial ►Analysis ►Reporting

7. Stages in a trial ►Planning and design ►Application for funding ►Conducting the trial ►Analysis ►Reporting Managers are important to all these

8. Vital contributions ►Project management ►Balancing resources, specification and timetable ►Skills in delivering trials ►Folk knowledge ►Experience of overcoming difficulties ►Professional approach to regulatory environment ►Attitude

9. Design stage ►Deliverability ►Accurate estimation ►Timetable ►Costs and resources ►Specific design features ►Setting for recruitment ►Incentives ►documentation

10. Design into conduct ►Feasibility and pilot studies ►Designing for clear objectives ►Learning ►Using results to modify main study

11. Conduct stage ►Approvals ►Site set-up and management ►Managing people ►Employed ►Associated ►Senior investigators ►Managing resources ►Communication with funder

12. Later stages ►Continue to manage as part of the project ►Resources ►Individual contribution ►Transfer of care beyond the trial ►Ensure outputs are delivered ►Reporting lessons from the management of the trial

13. Challenges and hopes ►Complexity of the environment ►End-to-end contribution ►Delegation ►Having a voice ►More recognition ►More trial managers as grant applicants ►Better partnership ►Equal opportunities

14. Thank you ►For listening ►For managing so many successful trials And thereby improving the health of the population

15. www.netscc.ac.uk www.hta.ac.uk