1. LEHNINGER PRINCIPLES OF BIOCHEMISTRY
David L. Nelson and Michael M. Cox
LEHNINGER
PRINCIPLES OF BIOCHEMISTRY
Sixth Edition
CHAPTER 12
Biosignaling
© 2013 W. H. Freeman and Company

2. Five features of signal transducing systems

4. Six general types of signal transducers

5. The β-adrenergic receptor is a G protein-coupled receptor

6. Adenylyl cyclase produces cyclic AMP (cAMP) from ATP cAMP is a potent second messenger in epinephrine signaling

7. The GTPase switch Regulation of epinephrine signaling

8. Activation of cAMP-dependent protein kinase (PKA)

10. Epinephrine cascade

11. Desensitization of the β-adrenergic receptor in the continued presence of epinephrine

14. Hormone-activated phospholipase C (PKC) and inositol 1,4,5-triphosphate (IP3)

15. Calmodulin often mediates the effects of calcium

17. Insulin signaling The insulin receptor is a tyrosine kinase

18. The electrogenic Na+K+ ATPase produces a transmembrane electrical potential of about -60 mV (negative inside the cell)

19. Free energy change for charged molecule
DG = RT ln ( Cin / Cout) + FVm
Z=valence, F=96,500 J/V*mol, Vm=TM electrical potential (volts)

20. Role of voltage-gated and ligand-gated ion channels in neural transmission

21. The acetylcholine receptor ion channel

22. Steroid hormones