1. AMBULATORY BLOOD PRESSURE MONITORING HEALTH WATCH IN BRNO, CZECH REPUBLIC Homolka P., Siegelová J., Cornélissen G.*, Fišer B., Dušek J., Vank P., Mašek M., Halberg F.* Masaryk University, Brno, Czech Republic, *University of Minnesota, Minneapolis, MN, USA

2. Background About-weekly, half-weekly and/or circadian componentscharacterize systolic (S) and diastolic (D) BP, the circaseptan- to-circadian prominence tending to be larger in MESOR- (chronome [time structure]-derived average) hypertension.

3. Aim To assess the chronome of 7-day/24-hour blood pressure (BP) and heart rate (HR).

4. Subjects and methods BP and HR profiles at 30-min intervals from 179 subjects were analyzed by sphygmochron.

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8. CHAT BP overswinging „Circadian Hyper-Amplitude- Tension“ (CHAT), a vascular disease risk factor was detected in 8.5% and 7.0% (SBP/DBP). CHAT was associated with evening exercise in one subject. was detected in 8.5% and 7.0% (SBP/DBP). CHAT was associated with evening exercise in one subject.

9. HRV Decreased heart rate variability occurred in 2.2 %. Decreased heart rate variability is accomplist with increased sympathetic activity and increased cardiovascular risk.

10. MESOR In data from the first 179 profiles (49 F, 130M, 20-77 years of age), women had a lower SBP- MESOR (P=0.026) and a higher HR-MESOR (P=0.005) than men. SBP increased linearly with age (r=0.341, P<0.001). The MESORs of DBP and HR and the circadian amplitudes of SBP and DBP followed a quadratic model, reaching maxima values around 40-60 years of age.

11. The 7-day and 3.5-day amplitudes of BP and HR were correlated (P<0.001), as were the 3.5-day and circadian amplitudes of SBP (P=0.004) and HR (P=0.013). The 7-day and circadian amplitudes of SBP (P=0.067) and DBP (P=0.046) were weakly associated. Circaseptan component is statistically significant for blood pressure but not for heart rate. The half-week is significant for all 3 variables, as is the circadian rhythm. The acrophases are around mid-week and mid-afternoon for the week and day, respectively. RHYTHM

12. CONCLUSION Gender differences and changes with age are keeping with earlier independent investigations. CHAT was detected in 8.5% and 7.0 % (SBP/DBP). Decreased heart rate variability occurred in 2.2 %. Support: MSM0021622402