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Increased peripheral platelet destruction and caspase-3– independent programmed cell death of bone marrow megakaryocytes in myelodysplastic patients by.

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Presentation on theme: "Increased peripheral platelet destruction and caspase-3– independent programmed cell death of bone marrow megakaryocytes in myelodysplastic patients by."— Presentation transcript:

1 Increased peripheral platelet destruction and caspase-3– independent programmed cell death of bone marrow megakaryocytes in myelodysplastic patients by Ewout J. Houwerzijl, Nel R. Blom, Johannes J. L. van der Want, Henk Louwes, Mariet T. Esselink, Jan W. Smit, Edo Vellenga, and Joost Th. M. de Wolf Blood Volume 105(9):3472-3479 May 1, 2005 ©2005 by American Society of Hematology

2 Correlation between the glycocalicin (GC) index and the platelet production rate (PPR). Ewout J. Houwerzijl et al. Blood 2005;105:3472-3479 ©2005 by American Society of Hematology

3 Ultrastructure of megakaryocytes from a healthy bone marrow donor and an MDS patient. Ewout J. Houwerzijl et al. Blood 2005;105:3472-3479 ©2005 by American Society of Hematology

4 Correlation between the percentage of MDS megakaryocytes in programmed cell death (PCD) and the number of platelets. Ewout J. Houwerzijl et al. Blood 2005;105:3472-3479 ©2005 by American Society of Hematology

5 Immunohistochemical detection of activated caspase-3 in megakaryocytes from a healthy donor, and MDS and ITP patients. Ewout J. Houwerzijl et al. Blood 2005;105:3472-3479 ©2005 by American Society of Hematology

6 Activated caspase-8 in megakaryocytes from a healthy donor and MDS patients. Ewout J. Houwerzijl et al. Blood 2005;105:3472-3479 ©2005 by American Society of Hematology


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