1. APPLICATION TO THE HADROTHERAPY FOR OCULAR MELANOMAS G.A. Pablo Cirrone Qualified Medical Physicist and PhD Student University of Catania and Laboratori Nazionali del Sud INFN, Italy

2. LNS Superconducting Cyclotron in Catania is the unique machine in in Italy and South Europe used for protontherapy

3. Depth doses in radiotherapy: single fields

4. Why clinical proton beams? penetration depth is well-defined and adjustable most energy at end-of -range protons travel in straight lines dose to normal tissue minimised no dose beyond target

5. MEDICAL APPLICATION OF THE CATANA FACILITY INFN - LNS Choroidal Melanoma 85 - 90 % successfully treating with proton beams About 300 new cases for year in Italy In the world 5000 patients have been already treated with proton beams Age related subfoveal macular degenerations with subretinal neovascular membrane This is the main cause of third age blindness in EC countries It is a “social disease” for EC

6. 0 ° respect the switching magnet 80 meter after extraction 3 m proton beam line LAYOUT OF LNS PRESENT TREATMENT ROOM

7. Scattering system Modulator & Range shifter Monitor chambers Ligth field Laser

8. Patient ready for treatment

9. DETECTORS USED FOR DOSE DISTRIBUTION MEASUREMENTS DEPTH DOSE DISTRIBUTION Markus Ionization chamber Silicon diode 2 mm Sensible Volume = 0.05 cm 3 LATERAL DOSE DISTRIBUTION GAF Chromic Film Thermoluminescent dosimeters Risolution 100  m for DDP and 200  m for LDP Markus Chamber layoutIrradiated GAF Chromic

10. ‘PURE’ BRAGG PEAK EXPERIMENTAL RESULTS

11. MODULATED BRAGG PEAK

12. EXPERIMENTAL LATERAL DOSE DISTRIBUTION

13. Geant4 applications in prothon therapy our goals Simulation, design and realization of critical elements of a proton beam lineSimulation, design and realization of critical elements of a proton beam line  Scattering systemScattering system  Modulation systemModulation system  Collimators along the beam lineCollimators along the beam line Three dimensions dose distribution verification in water at isocenter in the treatment conditionsThree dimensions dose distribution verification in water at isocenter in the treatment conditions Comparison with experimental and treatment planning data

14. G. Cuttone Project Leader INFN G.A.P. Cirrone Qualified Medical Physicist and PhD student V. Salamone L. Raffaele M.G. Sabini L. Valastro P. Lojacono V. Patti Proton therapy group in Catania Qualified Medical Physicist Student for Medical Physics Qualification