1. Tracking Cancer Development and Movement Interim Presentation February 19, 2005 Team 004 Albuquerque Academy Team Members: Punit Shah Karalyn Baca Teacher:Jim Mims Mentor:Dr. Gene Wong

2. 2February 19, 2005 Tracking Cancer Development and Movement Contents Project Objectives Research Math Model Code & Program To Do Questions

3. 3February 19, 2005 Tracking Cancer Development and Movement Project Objectives To model the development and propagation of melanoma skin cancer To see the patterns in the movement of the melanoma cancer through the body

4. 4February 19, 2005 Tracking Cancer Development and Movement Research Basic anatomy of skin Layers Epidermis, outermost layer of skin Germinal layer, where new skin is produced Dermis, where blood vessels, hair follicles, and such are Melanocytes Between germinal layer and dermis Make the pigment that in turn makes the skin whatever color it is

5. 5February 19, 2005 Tracking Cancer Development and Movement Research What causes skin cancer On a cellular level Cells are genetically changed by UV rays As they are unnatural, they thrive and continue to grow They make greater and greater pigment in the melanocytes There are predetermined factors and environments that increase the change of getting cancer Ways to protect from UV rays

6. 6February 19, 2005 Tracking Cancer Development and Movement Research How malignant melanocytes develop Their effect on the germinal layer and epidermis The movement of malignant cells at a local region The movement of malignant melanocytes through the body Their effect on organs The symptoms of melanoma The effects of malignant melanocytes on other cells and tissues

7. 7February 19, 2005 Tracking Cancer Development and Movement Math Model Initially, tumor growth is exponential As competition increases, cells start to die Cancer growth follows a sigmoidal curve A sigmoidal curve

8. 8February 19, 2005 Tracking Cancer Development and Movement Math Model Cancer starts as a sphere When cancer spreads, tends to spread horizontally rather than vertically When it continues, smaller tumors are created that continue the cycle To compute, we must look at many tumors’ development at once Uses great computing power, must be simplified Resource burdening will not be incorporated initially

9. 9February 19, 2005 Tracking Cancer Development and Movement Math Model Will start with taking few factors into account Will look at a simple, spherical growth and may have possible lateral spread in initial version When diameter exceeds 5mm, new tumors created around old tumor Old tumor will then die

10. 10February 19, 2005 Tracking Cancer Development and Movement Code & Program Microsoft Visual Basic 6.0 will be used Basic code has been developed and windows have been setup Plan to have two output windows Skin Model with cancer Time to Cancerous Cell count graph Program’s splash screen

11. 11February 19, 2005 Tracking Cancer Development and Movement Code & Program Plan to have procedures of classes be the different properties of a cell in the model Properties include Cancerous on non-cancerous Cancerous on non-cancerous Location in respect to different cancer tumors Location in respect to different cancer tumors An array will hold the different cells of the model The GUI of the model will be updated periodically to show progress

12. 12February 19, 2005 Tracking Cancer Development and Movement Code & Program The cancer model Time Cancerous Cell Count The cancerous cell count graph The cancer tumor

13. 13February 19, 2005 Tracking Cancer Development and Movement To Do Complete program Develop code to properly graph number of cancerous cells Add variables of growth such as partial treatment and random growth Show the cancer’s effect on other body parts Add the growth of satellite nodules Track general movement and growth throughout the body Thoroughly benchmark and test the program

14. Tracking Cancer Development and Movement Interim Presentation February 19, 2005 Team 004 Albuquerque Academy Team Members: Punit Shah Karalyn Baca Teacher:Jim Mims Mentor:Dr. Gene Wong