1. Data Science for FDA RFI Dr. Brand Niemann Director and Senior Data Scientist/Data Journalist Semantic Community http://semanticommunity.info/ http://www.meetup.com/Federal-Big-Data-Working-Group/ http://semanticommunity.info/Data_Science/Federal_Big_Data_Working_Group_Meetup April 6, 2015 1

2. Overview FedBizOpps.Gov FDA RFI: Web Word Drugs @ FDA Drug Approvals and Databases FDA Acronyms & Abbreviations NIH NIDA Data Share: Home NIH NIDA Data Share: Data Share Files Data Science for FDA RFI: MindTouch Knowledge Base MindTouch Attachments File Folder Excel Knowledge Base TIBCO Spotfire: Opening Screen Add Data Tables Make Inspired Discoveries About Your Data Recommended Visualizations 1 Recommended Visualizations 2 Cover Page PD Visualizations PD Data Some Conclusions and Recommendations 2

3. Advanced Analysis and Visualization of Both Clinical and Non-clinical Drug Application Data: FedBizOpps.gov https://www.fbo.gov/index?s=opportunity&mode=form&id=c2c0db8e6245c22f34f80db110626b70&tab=core&_cview=1 3

4. Advanced Analysis and Visualization of Both Clinical and Non-clinical Drug Application Data: Word https://www.fbo.gov/utils/view?id=be7cfc310663bd5d8979a88718decea8 4

5. Drugs @ FDA http://www.accessdata.fda.gov/scripts/cder/drugsatfda/ 5

6. Drug Approvals and Databases http://www.fda.gov/Drugs/InformationOnDrugs/default.htm 6

7. FDA Acronyms & Abbreviations 7 http://www.fda.gov/AboutFDA/FDAAcronymsAbbreviations/default.htm

8. NIH NIDA Data Share: Home 8 https://datashare.nida.nih.gov/

9. NIH NIDA Data Share: Data Share Files 9 https://datashare.nida.nih.gov/protocol/data

10. Data Science for FDA RFI: MindTouch Knowledge Base 10 http://semanticommunity.info/Data_Science/Data_Science_for_FDA_RFI

11. Data Science for FDA RFI: MindTouch Attachments 11 http://semanticommunity.info/Data_Science/Data_Science_for_FDA_RFI

12. Data Science for FDA RFI: File Folder 12 C:\Users\Brand Niemann\DoingDataScience\FDARFI

13. Data Science for FDA RFI: Excel Knowledge Base 13 http://semanticommunity.info/%40api/deki/files/32703/FDARFI.xlsx?origin=mt-web

14. TIBCO Spotfire: Opening Screen 14

15. TIBCO Spotfire: Add Data Tables 15

16. TIBCO Spotfire: Make Inspired Discoveries About Your Data Spotfire Suggestions helps you get insights quicker - regardless of whether you are an experienced analyst or a newcomer to visual analytics. Spotfire Suggestions allows you to look your data from different angles, discover new insights, and get a visual overview of your data - all this faster than ever! When you load new data, the first thing you see is the Suggestions window. Here, you can see all your data columns to the left. Select which columns interest you (click and hold CTRL to select more than one column), and alternative visualizations of your data will display on-the-fly. Start with one column, and see the distribution of the data. Add more columns and see relations between them, how measures are distributed amongst categories, or even view your data on a map. 16 https://spotfire.cloud.tibco.com/tsc/#!/whatsnew/november_2014/discover-data

17. TIBCO Spotfire: Recommended Visualizations 1 17

18. TIBCO Spotfire: Recommended Visualizations 2 18

19. TIBCO Spotfire: Cover Page 19

20. TIBCO Spotfire: PD Visualizations 20

21. TIBCO Spotfire: PD Data 21

22. Some Conclusions and Recommendations The FedBizOpps.Gov FDA RFI was mined for unstructured and structured content. Data Science for FDA RFI was to put the FDA RFI unstructured and structured content into a MindTouch Knowledge Base with file attachments and an Excel spreadsheet. The Excel spreadsheet (5 tabs) and sample NIH NIDA Data Share spreadsheets (27) were imported into TIBCO Spotfire for Exploratory Data Analysis. TIBCO Spotfire Recommendations to Make Inspired Discoveries About Your Data are illustrated. The same data science mining and visualization process could be used for the other 38 NIH NIDA Data Share studies. 22