1. Jonathan Ims BME 281 Sec. 1

2.  1964, Folkman demonstrated a silicon rubber pill for low molecular weight drugs.  1970s, Langer expanded on Folkman ◦ Polymers that could carry macromolecules  Mid 1990’s the idea of a drug releasing microchip by J. Santini Jr. ◦ J. Santini Jr. went to MIT

3.  Mechanical Micro Pumps ◦ Need a physical actuator  Non-mechanical Micro Pumps ◦ Converts some form of energy into kinetic momentum  Key components  High Flow Rate  Low Voltage (between 5 -12V)  Reliability of the System  Bio-compatibility  Frequency

6.  The width and length of each chip varies but the depth of the chip remains between (0.5mm to 1mm)  8 reservoirs can be found in an area of 1.77mm by 1.44mm  The reservoirs can hold a total of 200nL

7.  Patients with Chronic Disease ◦ Diabetes ◦ Epilepsy ◦ Osteoporosis ◦ etc.  It is not meant to replace prescription pills for common illnesses such as the flu.

8.  Surgery  Unwanted Side Effects ◦ Heat ◦ Pressure ◦ pH ◦ Bio-compatibilty  Reservoir size

9.  Increase the efficiency of drug delivery  Self-drug releasing chips  Different types of drug release  Better bio-materials