1. Biology Today Third Edition Chapter 15 Mind and Body Copyright © 2004 by Garland Science Eli Minkoff Pam Baker

2. Health What is it? systems in balance (homeostasis)

3. Health Factors affecting health genetics lifestyle diet exposure

4. Health psychoneuroimmunology mindnerves immune

5. Immune system innate the body can protect itself from invasion skin in a barrier

6. Immune system innate the body responds to damage - inflammation hot, red, swollen, sore

7. fig. 15-1

8. fig. 15-3

9. Figure 15.2

10. Filarial worm gets into body blocks lymphatics fluid accumulates. Elephantiasis

11. Vertebrates have a second immune system specific immunity

12. protects us against future exposure to some diseases

13. antigens (foreign) molecules that can be detected by the immune system parts of bacteria, viruses, cancer cells,…

14. Figure 15.1

15. lymphocytes B-cells T-cells make antibodies various kinds

16. B-cells antibodies proteins bind to antigens help kill cells or signal destruction each B cell can make only one antibody

18. B-cells can recognize molecules distinguish self from nonself remembers exposure BT3, pg. 548

19. Figure 15.4b

20. Figure 15.4c

21. Figure 15.4d

22. Figure 15.4e

23. T-cells various kinds T c -cells cytotoxic T h -cells helper T s -cells supressor T m -cells memory CD4 + CD8 +

24. Figure 15.4a

25. Memory Once exposed to an antigen, the body has cells that remember

26. Memory announcements Blood drive (10 pts) Dec 3-6 (M-Th) 12:30 to 6:30 Jones Conference Room

27. 0 1 2 3 4 t 1/2 = ?1/2 hr

28. 0 1 2 3 4 * * * * t 1/2 = 1 hr ?

29. 0 1 2 3 4 * * * *

30. Figure 15.5

31. When you make antibodies: active immunity exposure to disease vaccination

32. When you acquire antibodies: passive immunity newborn snakebite (antibodies from someone else)

33. Figure 15.6

34. Active immunity vs. Passive immunity

35. Abnormal immune system Autoimmunity (self immunity) multiple sclerosis (MS) IDDM …

36. Abnormal immune system Allergies allergens (antigens) mast cells and IgE histamine

37. Figure 15.7

38. Abnormal immune system Transplant disease match tissue (perfect match is rare) suppress immune system

39. Immunosuppression inhibition of immune system drugs (transplant) overnutrition protein undernourishment infant undernourishment micronutrients diseases (AIDS - T h cells)

40. Link between immune system and nervous system Autonomic nervous system (self-regulating) Regulates body functions Not conscious Two divisions sympathetic, parasympathetic

41. Figure 15.8 normal resting activity flight or fight

42. stress Fight/flight response first step in a series of physiological responses nervous system immune system endocrine system

43. fig. 15-9

44. nervous system immune system endocrine system linked

45. Evidence Shared signaling molecules (cytokines) Nerve ending in immune organs

46. Placebo effect Control to experimental group new pill pain killer + sugar control pill sugar only reduce pain?

47. Figure 15.11

48. The mind is connected to our immune system and our endocrine system, which can, in turn affect our health (balance).