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Published byFrank Fowler Modified over 9 years ago
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Principles of Immunology Autoimmunity 4/25/06
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Organs Specific Autoimmune Diseases Hashimoto’s thyroiditis DTH like response to thyroid Ags Ab to thyroglobulin Hypothyroidism Pernicious anemia Ab to gastric parietal cells Interferes with vitamin update Reduced RBCs
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Organs Specific Autoimmune Diseases Goodpasture’s syndrome Ab to Ag on basement membranes C activation Glomerulonephritis, pulmonary disease Type 1 diabetes Ab to beta cells of pancreas DTF reaction Cytokine induced damage
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Organs Specific Autoimmune Diseases Myasthenia gravis Ab to acetyl choline receptors Blocks muscle activation C activation and damage to muscle cells
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Systemic Autoimmune Disease SLE Ab to certain tissue antigens Vasculitis Diagnosis using anti nuclear antibodies MS Reaction to myelin sheath Viral component?
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Systemic Autoimmune Disease Rheumatoid arthritis IgM which is anti IgG Immune complexes Chronic inflammation
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Genetics vs. Environment HLA type Sequestered antigens
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CD4 Cells and Autoimmune Disease Transferable Anti CD4 Ab protective
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Mechanisms Release or expression of Ags Cross reacting Ags
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Therapies Cyclosporin Interferes with T cell development Anti-inflammatories
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