1. NIH NeuroBioBank: A Platform for Postmortem Brain Research Michelle Freund, PhD AFSP Forum February 28, 2014

2. What is the NeuroBioBank? 2 A federated brain and tissue repository network integrated by an IT system Brain and tissue repositories are now being supported with contracts (NIMH, NINDS and NICHD) Focus on quality management, sharing, outreach

3. 3 https://neurobiobank.nih.gov

4. Why are we doing this? 4 Increase the availability of tissue Standardize quality metrics Return data derived from banked tissues to public database Opportunities for discovery have never been greater (genetics, iPSCs, and –omics,)

5. The NIH NeuroBioBank for tissue access 5 Include specimen inventory and access information Set tissue quality and data standards Information/training for investigators Forum for collaboration among BTR Directors

6. 6 Advocacy Groups Public & Patient Populations Research Community Brain Bank A Neurobiobank Web Portal Biospecimen inventory and access information Information for the public Standards for tissue and data Standards for patient data, consent forms Brain Bank B Brain Bank C Brain Bank D The NIH NeuroBioBank for tissue access

7. Status of the NIH NeuroBioBank 7 NeuroBioBank IT Portal is now live with information for the public, researcher site in development Contracts were awarded to five Brain and Tissue Repositories on September 1, 2013 University of Miami, Deborah Mash Harvard University, Francine Benes Mt. Sinai, Harry Haroutunian Sepulveda Research, Rashed Nagra University of Pittsburgh, David Lewis Efforts to centralize/standardize toxicology testing are underway Solicitation for FY14 was issued and proposals are due Feb 18, 2014.

8. Status of the NeuroBioBank 8 Neurobiobank implementation will focus on : ■ Quality Management (uniform measures) ■ Increasing tissue and data access ■ Setting Standards (phenotype and tissue quality and characterization) ■ Outreach

9. Increase access to human tissues Geographically distributed brain and tissue repositories Increase public awareness/prospective donation Partner with disease advocacy communities and local medical examiners to increase donation Incentivize current bankers to increase diversity of donor pool

10. NIH NeuroBioBank NICHD NIMHNINDS Thank You