1. 1970s 1975 1980 1985 1990 1992 1994 1995 1996 1997 1998 1999 2000 2001 2002 2004 2006 Functional Genetics From … Functional Genomics … to … Evolution of biomedical innovation potential …

2. An Integrative Approach for Discovery of Gene Function in Immunological Disease New Animal Models Functional Genetics Molecular & Cellular pathways Sensitized ENU mutagenesis Expression profiling Cross platform validation (GO, QTLs, human) Gene & pathway prediction Gene & pathway validation in animal models

3. New knowledge & Innovation € € Research Business

4. The Greek perspective; Can we succeed in a new knowledge-driven economy? Excellent Greek scientists exist all over the world (including Greece) EU membership Small country providing advantages on focus and synergies

5. Biomedical Research highly fragmented Biomedical Research highly fragmented National Policies and Instruments still pending National Policies and Instruments still pending Industrial collaborations without impact Industrial collaborations without impact Nuclei of excellence still exist Nuclei of excellence still exist Reforms and investment necessary Reforms and investment necessary … on research … on research

6. A few Recommendations for an Integrated Support of the Greek Research Environment Integrated design based on excellence and first-rate scientists Meritocracy and accountability – follow international standards Foster creative research careers of outstanding young researchers Develop large infrastructures / projects needed for innovation Incubate technology transfer structures with free academic research Invest more on Research Institutes (rather than Universities) Reform National Research Funding System (involve stakeholders)

7. Lack of entepreneurship and business skills Lack of entepreneurship and business skills Little help for start-ups Little help for start-ups (IPR management, financing, management) (IPR management, financing, management) Limited access to knowledge portfolios Limited access to knowledge portfolios Need for a common vision between R&B Need for a common vision between R&B Reforms and investment necessary Reforms and investment necessary … on commercialization … on commercialization

8. A few Recommendations for an Integrated Support of the Greek Innovative Business Environment High standards incubating facilities / clusters IPR assistance and management for Biotech Financing and further organizational support Support for further R&D in start-ups Integrated National Innovation System Business start-up incentives and assistance or mentoring

9. BIOMEDICAL SCIENCES RESEARCH CENTRE ‘ALEXANDER FLEMING’ A European Centre of Excellence in Functional Genomics Mouse Clinic Technology Incubator Research Institutes (Vari – Greece)