1. Proteins Chapter 5 Big Idea #2: Structure Meets Function

2. Basic Unit of Proteins  Amino Acid:  Review:  What are the constant domains of an amino acid?  What is the variable region?

3. Types of Amino Acids  What functional groups can you recognize in the variable regions?  How might these impact how the variable region functions?

4. How does the amino acid chain dictate protein structure?

5. Modeling Activity  Let’s use pipecleaners to model protein structure.  What limitations do we have?

6. What impacts each level of structure?

7. Key Protein Functions  Can you give an example of each? (In case a multiple choice gives examples instead of categories?!)  Enzymes  Hormone  Receptor  Contractile  Defensive  Transport  Storage  Structural

8. Structure Meets Function  Case Study: Hemoglobin  What differs?  How might this cause such a significant change in protein structure?

9. Sickle Cell Disease

10. Structure Meets Function  Case Study: CJD and Prions  Prions: Misfolded proteins  Can be infectious agents!

11. Protein Project!!!  Goal:  To connect Big Ideas #1 & 3 (Evolution and continuity of proteins) to Big idea #2 (How proteins work) Work in Pairs By Function  Your job is to find TWO examples for each function and present a poster session to connect the two examples.  Research structure meets function using primary sources and figures from primary sources.  Research evolution using a BLAST to find and compare similar protein sequences in various organisms.