1. Chapter 25 Care of Patients with Infection Mrs. Kreisel MSN, RN NU130 Adult Health 1 Summer 2011

2. Definitions Pathogen—any microorganism capable of producing disease Communicable—infection transmitted from person to person Pathogenicity—the ability to cause disease Virulence—the degree of communicability

3. Definitions (Cont’d) Normal flora—characteristic bacteria of a body location; it often competes with other microorganisms to prevent infections Colonization—the microorganism present in tissue but not yet causing symptomatic disease Surveillance—the tracking and reporting of infections

4. Overview of Chain of Infection Reservoirs Pathogens: Toxins Exotoxins: A toxin produced by a microorganism and excreted into its surrounding tissue. (liquid medium, unstable, light, heat and chemical sensitivity) Endotoxins: bacterial toxin confined within the body of the bacterium, freed only when the bacterium is broken down. Host Defenses: Susceptibility

5. Immunity Resistance to infection is usually associated with the presence of antibodies or cells acting on specific microorganisms. Passive immunity is of short duration, either naturally by placental transfer or artificially by injection of antibodies. Active immunity lasts for years and occurs naturally by infection or artificially by stimulation (vaccine) of immune defenses

6. Antibodies

7. Antibodies Mechanism of Action

8. Portal of Entry Sites Respiratory tract GI tract Genitourinary tract Skin/mucous membranes Bloodstream

9. Mode of Transmission Contact transmission by direct or indirect contact Droplet transmission such as in influenza Airborne transmission such as in tuberculosis Contaminated food or water Vector-borne transmission involving insect or animal carriers, such as in Lyme disease Portal of exit

10. Physiologic Defenses Against Infection Body tissues Phagocytosis Inflammation Immune systems: Antibody-mediated immune system Cell-mediated immunity

11. Infection Control in Inpatient Health Care Agencies Health care–associated Infection (HAI) is acquired in the inpatient setting; not present at admission. Endogenous infection is from a patient’s flora. Exogenous infection is from outside the patient, often from the hands of health care workers.

12. Methods of Infection Control Practice hand hygiene and proper handwashing. Personal protective equipment (PPE).

13. Nurse in Personal Protective Equipment Caring for Patient in Protective Isolation Room EDUCATION TO FAMILY ABOUT PPE

14. Infection Control Adequate staffing Sterilization: free from all microorganisms and spores Disinfection: Kills most microorganisms but not spores Patient placement: Cohorting: pts with same illness placed together Patient transportation: PPE if necessary

15. CDC and Prevention Transmission–Based Guidelines Standard Precautions: Respiratory hygiene/cough etiquette (RH/CE) Safe injection practices

16. Transmission-Based Precautions Airborne Precautions Droplet Precautions Contact Precautions KNOW PAGE 447

17. Methicillin-Resistant Staphylococcus Aureus (MRSA) Vancomycin Linezolid Community-associated MRSA The best way to decrease the incidence of this growing problem is health teaching CONTACT PRECAUTIONS/ISOLATION

18. Other Multi Drug Resistant Organisms (MDROs) Vancomycin-resistant Enterococcus (VRE) Multidrug resistant tuberculosis Gonorrhea Vancomycin-intermediate Staphylococcus aureus (VISA) Vancomycin-resistant S. aureus (VRSA)

19. Problems from Inadequate Antimicrobial Therapy Noncompliance (deliberate) or nonadherence (accidental) Legal sanctions that compel a patient to complete treatment, such as in the instance of tuberculosis (Directly Observed Therapy DOT) Septicemia Septic shock

20. Collaborative Care History Physical assessment and clinical manifestations Psychosocial assessment Laboratory assessment including: Culture and antibiotic sensitivity testing Complete blood count Erythrocyte sedimentation rate Serologic testing Imaging assessment

21. Community-Based Care Home care management Health teaching Health care resources

22. NCLEX TIME

23. Question 1 How many inpatients acquire health care– associated infections yearly? A.500,000 B.1,000,000 C.1,500,000 D.2,000,000

24. Question 2 Cleansing hands with alcohol-based hand rubs is appropriate in which situation? A.After administering medications to a patient B.After working with a patient who has diarrhea due to Clostridium difficile C.After using the bathroom D.To cleanse visibly soiled or sticky hands

25. Question 3 A patient who has been admitted for newly diagnosed tuberculosis will be placed on which Transmission-Based Precaution? A.Droplet Precautions B.Airborne Precautions C.Respiratory Precautions D.Contact Precautions

26. Question 4 A patient may have infectious mononucleosis and is awaiting laboratory confirmation of this diagnosis. If the results are positive for infectious mononucleosis, the nurse would expect to see which laboratory result? A.Increased neutrophil levels B.Decreased neutrophil levels C.Decreased erythrocyte sedimentation rate D.Increased lymphocyte levels

27. Question 5 Which person has the highest risk for having Clostridium difficile–associated disease (CDAD)? A.A poultry farm worker B.A person who has eaten a hamburger that was cooked rare C.A 2-year-old patient who has received IV antibiotics for a week D.An 82-year-old patient who has received IV antibiotics for a week