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Molecular biology and evolution in genomics era Li Jun and Frederick C.C. Leung 5N01, School of Biological Science, The University.

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Presentation on theme: "Molecular biology and evolution in genomics era Li Jun and Frederick C.C. Leung 5N01, School of Biological Science, The University."— Presentation transcript:

1 Molecular biology and evolution in genomics era Li Jun and Frederick C.C. Leung (fcleung@hkucc.hku.hk) 5N01, School of Biological Science, The University of Hong Kong

2 Genotype designation according to phylogenomic tree Virus evolutionary and epidemiology study Geographic transmission of virus Estimation of time of the most recent common ancestor (tMRCA)

3 Web based tool for PRRSV molecular epidemiology and evolutionary analysis

4 Genome sequencing and assembly o Gaps are randomly dispersed in the chromosome. Most of the large gaps reside in RNA gene regions. o Read coverage along the genome are nearly uniform, with mild random fluctuation. o Only ~10 potential mis- assembled regions can be detected when sequencing depth is >10x.

5 RNA seq and differential gene expression analysis

6 Metagenomics


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