1. Ch 12 Cardiovascular Physiology
Finish Section A
Begin Section B The Heart
Lab is ~ 2hrs this week SPSS Abstracts due 7 Nov Editorial help before submission?

2. What’s missing? Microcirculation Exchange Vessels Pulmonary circuit
5 liters/min
5 liters/min
Systemic Circuit
Resistance Vessels
Microcirculation
Exchange Vessels
Capacitance vessels

3. Q= ΔP πr4 8Lη Poiseulle’s equation
Flow = Pressure gradient/Resistance
A version of Ohm’s Law (V=IR)
Radius of arterioles regulates Q to organs
Double radius … 16x flow
Half radius….1/16th flow
R = 8Lη/πr4
Q= ΔP πr4 8Lη Poiseulle’s equation
Smooth muscles determine radius

4. Cardiac Output = Heart Rate X Stroke Volume CO = HR x SV 5L/min = 72 beat/min x 70 ml/beat

5. Figure 12.07 Tricuspid Bicuspid =Mitral Problems with valves:
….Stenosis (narrowing) →Heart Murmurs (turbulent flow past a constriction)
note: origin of neonatal heat murmurs (foramen ovale)
….Prolapse (eversion) allows backflow (also generates murmurs)
Figure 12.07
Bicuspid =Mitral
Tricuspid
Heart sounds and valve closings
Semilunar Valves

6. Figure 12.11
SA node cells spontaneously produce AP, do not have stable resting membrane potential, are Pacemaker cells

7. Figure 12.25
Contractility