1. Collaboration with the COPDgene Group & priorities for REG Richard Martin 9:40–10.00

2. Initiatives Validation of end points Validation of real-life diagnostic criteria where no code exists Health care utilization and therapy in COPD based on CT lung phenotyping

3. COPDgene Group ~10,000 COPD patients well-categorized Unique o CT lung phenotyping –Emphysema ± –Air trapping ± –Mixture o Social security numbers o ⅓ are black Medicare database (≥ 65 y/o)

4. COPDgene Group Telephone survey—symptoms Not health care utilization Not by CT phenotype

5. COPDgene Patients: real-life trials Health care utilization by CT phenotype o Hospitalizations –O2 use –Meds –Procedures –Other costs – ICU, etc. ED o As above Above for blacks (1/3 of sample size) Influenza/Pneumovac vaccinations (?)

6. Funding NHLBI ancillary trials—D/C Pharma o BI o GSK o AZ