1. Design and Analysis of Matched Data Presenter: DAVID G. KLEINBAUM Dept. of Epidemiology Dept. of Epidemiology Rollins School of Public Health Rollins School of Public Health Emory University Emory University Atlanta, GA Atlanta, GA

2. Part 0: ACTIVEPI A MULTIMEDIA CD ROM COURSE ON FUNDAMENTALS OF EPIDEMIOLOGY

3. OUTLINE: MATCHING IN EPIDEMIOLOGIC RESEARCH (Part 1) Definitions Types of Matching Matching Ratios Reasons for Matching Reasons Against Matching To Match or Not to Match ?

4. MATCHING OUTLINE continued (Part 2- ANALYSIS) Options and General Principles Pair-Matched Case-Control Data R-to-1 Matched Case-Control Data Frequency-matched Data Logistic Regression Modeling Pair-Matched Cohort Data

5. MATCHING OUTLINE continued (Part 3- OTHER ISSUES) Pooling Exchangeable Matched Sets Assessing Interaction For Matched Variables Breaking the Matching Ignoring the Matching Anything else ?

6. COURSE PREREQUISITES (HOPEFULLY) Basic principles and methods of epidemiology (e.g., study designs, measures of disease frequency and effect, confounding, effect modification) Basic principles and methods of biostatistics (e.g., standard error, tests of hypothesis, confidence intervals, P-vales) Some background in logistic regression methods (e.g., the model form, the logit function, odds ratio estimate) Some experience with computer packages (e.g., SAS, STATA, SPSS)

7. ActivEpi WHAT IS IT? A CD-ROM MULTIMEDIA LEARNER-INTERACTIVE COURSE ON FUNDAMENTALS OF EPIDEMIOLOGY (FOR WINDOWS AND MAC) (FOR WINDOWS AND MAC)

8. ActivEpi WHO DEVELOPED IT? DAVID G. KLEINBAUM- AUTHOR DATA DESCRIPTION (Ithaca, NY)- MEDIA TECHNOLOGY MEDIA TECHNOLOGY SPRINGER-VERLAG- PUBLISHER

9. ActivEpi Course outline covers topics in most intro epi texts (e.g., Kleinbaum, Kupper, & Morgenstern, Rothman-Greenland, Kelsey)Course outline covers topics in most intro epi texts (e.g., Kleinbaum, Kupper, & Morgenstern, Rothman-Greenland, Kelsey) Chapter Topics (e.g., Measures of Disease Frequency, Measures of Effect, Confounding) are called “Lessons”Chapter Topics (e.g., Measures of Disease Frequency, Measures of Effect, Confounding) are called “Lessons” 15 Lessons, each with several “Activities”15 Lessons, each with several “Activities” (NOTE: LESSON 15- MATCHING) (NOTE: LESSON 15- MATCHING) HOW ORGANIZED?

10. All 15 Chapters (Lessons) Completed All 15 Chapters (Lessons) Completed Golden Master CD sent to Publisher- May 15 2002 Golden Master CD sent to Publisher- May 15 2002 ActivEpi Companion Text- to be completed June 2002 ActivEpi Companion Text- to be completed June 2002 Purchase Price of CD- approx $US 70 Purchase Price of CD- approx $US 70 Purchase Price of Companion Text: approx $US 20) Purchase Price of Companion Text: approx $US 20) Availability for Purchase: September 2002 Availability for Purchase: September 2002 ActivEpi CURRENT STATUS?

11. INTRODUCTION AND DEFINITION OF MATCHING

16. MATCHING ? A Design Option for the Control of Extraneous Variables Experimental Studies Observational Cohort Studies Observational Case-Control Studies

17. Definition