1. COST is supported by the EU RTD Framework Programme ESF provides the COST Office through an EC contract European network on applications of Atomic Force Microscopy to NanoMedicine and Life Sciences AFM4NanoMed&Bio TD1002 Action Chair: Pierre Parot Rapporteur: Pavle Andjus Science Officer: Magdalena Radwanska Start date: 13/12/2010 End date: 12/12/2014

2. COST is supported by the EU RTD Framework Programme ESF provides the COST Office through an EC contract 2 Scientific background

3. COST is supported by the EU RTD Framework Programme ESF provides the COST Office through an EC contract What is Atomic Force Microscopy? What is Atomic Force Microscopy? Strength High signal to noise ratio (S/N) High signal to noise ratio (S/N) Measurement in physiological conditions (liquid) Measurement in physiological conditions (liquid) Possibility of coupling with other imaging and functional methods Possibility of coupling with other imaging and functional methods piezo Feedback Photodiode sample Cantilever tip laser Distance Force Scan mode Force mode

4. COST is supported by the EU RTD Framework Programme ESF provides the COST Office through an EC contract Weakness Complex instrument to manipulate Complex instrument to manipulate Upmost importance of the preparation of the sample Upmost importance of the preparation of the sample Need to improve speed, sensitivity and normalization Need to improve speed, sensitivity and normalization Membrane proteins Challenges in AFM for Clinical research Challenges in AFM for Clinical research

5. COST is supported by the EU RTD Framework Programme ESF provides the COST Office through an EC contract Why a COST Action now? Need: to establish equitable communication between physics and life sciences to train young scientists in this transdisciplinary domain to include manufacturers and R&D for improving machines

6. COST is supported by the EU RTD Framework Programme ESF provides the COST Office through an EC contract COST Action TD 1002 Website First WG meeting, Lamorlaye France, 10-13 May 2011

7. COST is supported by the EU RTD Framework Programme ESF provides the COST Office through an EC contract 7 Objectives based on the MoU

8. COST is supported by the EU RTD Framework Programme ESF provides the COST Office through an EC contract 8 Objectives based on the MoU - Promote the federation and integration of the European community of scientists involved in applying AFM to NanoMed&Bio. - Reinforce exchanges of scientific experiences specialized on biological applications. - Gather the knowledge to develop AFM into a tool for clinical diagnosis; - Explore novel applications of AFM in NanoMed&Bio, pharmaceutical, environmental and food industry. - Provide rigorous training for students and young scientists to efficiently master AFM operations in NanoMed&Bio. - Support Short-Term Scientific Missions of young investigators or students among physics and biomedical laboratories. 1980’s1990’s2000’s PhysicsBiophysicsBiologyMedicine 2020

9. COST is supported by the EU RTD Framework Programme ESF provides the COST Office through an EC contract 9 - The Action will efficiently transfer and continuously update knowledge from AFM researches to medical researchers and clinicians. - The Action will maintain the leadership of the European AFM groups in AFM technique developments and applications. - The Action will allow the concerted European standardization of laboratory and clinical methods including the rules and regulations of safety and security related to public health. COST Action expected results

10. COST is supported by the EU RTD Framework Programme ESF provides the COST Office through an EC contract 10 Action/Network structure

11. COST is supported by the EU RTD Framework Programme ESF provides the COST Office through an EC contract ACTION_TD1002 AFM4NanoMed&Bio 13/12/2010 – 12/12/2014 BMBS European network on applications of Atomic Force Microscopy to NanoMedicine and Life Sciences TDP Participating countries: AT BE CH DE DK ES FI FR GR HR HU IR IT IL LU NL PL PT UK Chair of the Action: Pierre Parot, FR, parot@cea.frparot@cea.fr COST Science Officer: Magdalena Radwanska Magdalena.Radwanska@cost.eu Action website: www.afm4nanomed&bio.orgMagdalena.Radwanska@cost.eu www.afm4nanomed&bio.org Kickoff Meeting took place on December 13th 2010 Next Meeting: August 2011 PARIS The main objective of the Action is to further develop and transfer the biophysical achievements of Atomic Force Microscopy to NanoMedicine and clinical research. AFM Training Center Hospital AFM lab Physician Scientist with Medical Project AFM newcomer Physician Scientist with AFM data AFM trained ESF provides the COST Office through a European Commission contract COST is supported by the EU RTD Framework Programme The Council of the European Union provides the COST Secretariat WG 3 Peter Schöen WG 4 Vesna Svetličić WG 5 Ricardo Garcia NanoMedicine Nanodiagnosis Nanosensing Applied WG that uses AFM with additional techniques: fluorescence, Raman, ion measurements… Environmental Nanotoxicology and Nanoparticles Applied WG that evaluates the use of AFM as a tool in nanoecology and nanotoxicology and health risk assessment Management Committee (MC) Chair: Pierre Parot Vice-Chair: Hans Oberleithner Task Group Coordinator: Jean-Luc Pellequer Working Group Coordinators WG 2 Salvatore Cannistraro Dynamic Force spectroscopy on Molecules and Cells WG promoting fundamental research based on the piconewton force sensitivity of AFM. WG 1 Simon Scheuring New Instrumentation and Techniques Special WG in relation with manufacturers concerning the specifications of standardized AFM Machines for clinical applications. Imaging from molecules to cells Fundamental WG that uses the basic strength of AFM: High Resolution Imaging

12. COST is supported by the EU RTD Framework Programme ESF provides the COST Office through an EC contract 12 What sort of COST would you like? and for Whom? COST Action management should be oriented to junior researchers. Could COST rules be formally changed in that way? What COST could do to help COST Actions reaching successful FP proposal? Who can in COST office help us to participate to the preparation of FP calls. Could COST imagine to increase the number of TD Actions?