1. Contact Information:E-mail: zengw@marshall.eduzengw@marshall.edu Tel: 304 696-3892

3. Regulation of Th Cell Subset Differentiation

4. Cell Lineage Plasticity of Treg Cells

5. Therapeutic Application of Treg Cells Therapeutic application of Foxp3-transduced Th cells in mouse models of human diseases. Left, inflammatory bowel diseases (massive inflammatory infiltration in the colon) were induced by adoptive transfer of CD25 - CD45RB h conventional CD4 T cells to immune deficient mice. However, co-transfer of Foxp3- transduced Th1 or Th17 cells greatly alleviate the diseases. Center and right, similarly, Foxp3-transduced Th cells suppressed disease development in the mouse models of multiple sclerosis and allergic asthma, respectively.